PDF(Pubmed)
Abstract：
Brucellosis is a highly contagious zoonotic disease and a major human health problem worldwide. Due to its ways of transmission, direct or indirect contact with infected animals or their contaminated biological products, the disease exhibits strong occupational association with animal handlers comprising a significant population at risk. This study was undertaken to estimate the seroprevalence of brucellosis in animal handlers and to understand the epidemiological and serological aspects of the same. The animal handlers from the state of West Bengal, India were included in this study. It was a prospective and observational cohort study from November 2021 to March 2022. A total of 669 sera samples were collected from animal handlers and tested using various serological tests for Brucella antibodies. All serum samples were tested using the Rose Bengal plate test (RBPT), standard tube agglutination test (STAT), and enzyme-linked immunosorbent assay (ELISA). 106 (15.8%) patients were diagnosed with brucellosis among the total number of patients tested. Most of the patients affected with brucellosis belonged to the age group 51-60 years (23.5%). The seropositivity rate in male animal handlers was higher than female animal handlers in this study. More studies are needed to understand the occupational association of this disease. Awareness programs, safe livestock practices, and prevention of the disease by timely diagnosis must be implemented in order to control human brucellosis.
摘要：
布鲁氏菌病是一种高度传染性的人畜共患疾病，是世界性的重大人类健康问题。由于其传播方式,直接或间接接触受感染的动物或其污染的生物制品，该疾病与动物饲养者有很强的职业关联，这些动物饲养者中有相当大的风险人群。进行这项研究是为了估计动物处理者布鲁氏菌病的血清阳性率，并了解其流行病学和血清学方面。来自西孟加拉邦的动物管理员，印度被纳入这项研究。这是一项前瞻性和观察性队列研究，从2021年11月到2022年3月。从动物处理人员收集了总共669份血清样品，并使用各种布鲁氏菌抗体的血清学测试进行了测试。所有血清样品使用玫瑰红板测试（RBPT）进行测试，标准管凝集试验（STAT），和酶联免疫吸附测定(ELISA)。在接受测试的患者总数中，有106例（15.8％）患者被诊断为布鲁氏菌病。大多数患有布鲁氏菌病的患者属于51-60岁年龄段（23.5％）。在这项研究中，雄性动物处理者的血清阳性率高于雌性动物处理者。需要更多的研究来了解这种疾病的职业关联。意识计划，安全的牲畜做法，为了控制人类布鲁氏菌病，必须通过及时诊断来预防疾病。
