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Abstract：
Objective The objectives of this study were to determine the frequency of the clinical spectrum of diseases in patients with macrocytosis and to summarize the diagnostic evaluation of patients found to have macrocytosis on laboratory testing. Background This was a cross-sectional study that took place at the Department of Medicine in Combined Military Hospital, Rawalpindi, Pakistan, from January to June 2023. Methodology One hundred and five patients with macrocytosis with mean corpuscular volume (MCV) values > 100 fL (80 to 100 fL) were inducted as per inclusion and exclusion criteria. Informed consent was obtained from all patients. Complete blood counts (CBC), peripheral blood film, serum vitamin B12 levels, serum folate levels, renal function tests (RFTs), liver function tests (LFTs), and thyroid function tests (TFTs) were performed during the assessment. Results The commonest cause of macrocytosis was vitamin B12 deficiency followed by folate deficiency, combined vitamin B12 and folate deficiency, and other causes were also found in a few cases. Conclusion Serum vitamin B12 and folate deficiency are the most common preventable causes of macrocytosis.
摘要：
目的本研究的目的是确定巨胞病患者的临床疾病谱频率，并总结实验室检查发现巨胞病患者的诊断评估。背景这是一项横断面研究，发生在联合军事医院的医学部，拉瓦尔品第,巴基斯坦,2023年1月至6月。方法根据纳入和排除标准，选择平均红细胞体积（MCV）值>100fL（80至100fL）的大红细胞增多症患者105例。获得所有患者的知情同意。全血细胞计数（CBC），外周血膜，血清维生素B12水平，血清叶酸水平，肾功能测试（RFT），肝功能测试（LFTs），和甲状腺功能测试（TFT）在评估过程中进行。结果大红细胞增多症最常见的原因是维生素B12缺乏，其次是叶酸缺乏。联合维生素B12和叶酸缺乏，在少数情况下还发现了其他原因。结论血清维生素B12和叶酸缺乏是巨细胞病最常见的可预防原因。
