PDF(Pubmed)
Abstract：
UNASSIGNED: Food allergies are serious and potentially life-threatening, and often place a large burden on patients and their caregivers, including impacts on quality of life.
UNASSIGNED: To assess the real-world patient burden of food allergies, using self-reported data available from the Food Allergy Research & Education (FARE) Patient Registry (NCT04653324).
UNASSIGNED: The FARE Patient Registry is voluntary and captures real-world experiences of adults and pediatric patients in the United States, and their caregivers, through a series of surveys assessing patient health and experiences with food allergies. Self-reported data were descriptively analyzed.
UNASSIGNED: The FARE study cohort included 5587 patients with food allergies; 82% had multiple food allergies and 62% were aged <18 years. About half of the patients were first diagnosed by an allergist/immunologist (53%), most commonly with a skin prick test (71%) or a serum immunoglobulin E test (62%). This analysis found that food allergies (most commonly peanut [66%], tree nuts [61%], egg [43%], and milk [37%]) impart a large clinical burden on patients, many of whom experience food-related allergic reactions and comorbidities. Many patients experienced >1 food-related allergic reaction per year (42%), with 46% experiencing food-induced anaphylaxis. Half of all food-related allergic reactions occurred at home. Accidental exposures to food allergens were experienced by 77% of patients. The most common allergic comorbidities reported by patients with food allergies were atopic dermatitis (48%), asthma (46%), and allergic rhinitis (39%). The clinical burden of food allergies were found to be greater in patients with multiple food allergies, and different for adults versus pediatric patients.
UNASSIGNED: This is the first study to assess patient experience and disease burden information from patients contributing to the FARE Patient Registry, thus providing a unique insight into the lives of patients in the United States with food allergies. These insights may assist clinicians and other public health stakeholders in the management of patients with food allergies.
UNASSIGNED: To assess the real-world patient burden of food allergies, using self-reported data available from the Food Allergy Research & Education (FARE) Patient Registry (NCT04653324).
UNASSIGNED: The FARE Patient Registry is voluntary and captures real-world experiences of adults and pediatric patients in the United States, and their caregivers, through a series of surveys assessing patient health and experiences with food allergies. Self-reported data were descriptively analyzed.
UNASSIGNED: The FARE study cohort included 5587 patients with food allergies; 82% had multiple food allergies and 62% were aged <18 years. About half of the patients were first diagnosed by an allergist/immunologist (53%), most commonly with a skin prick test (71%) or a serum immunoglobulin E test (62%). This analysis found that food allergies (most commonly peanut [66%], tree nuts [61%], egg [43%], and milk [37%]) impart a large clinical burden on patients, many of whom experience food-related allergic reactions and comorbidities. Many patients experienced >1 food-related allergic reaction per year (42%), with 46% experiencing food-induced anaphylaxis. Half of all food-related allergic reactions occurred at home. Accidental exposures to food allergens were experienced by 77% of patients. The most common allergic comorbidities reported by patients with food allergies were atopic dermatitis (48%), asthma (46%), and allergic rhinitis (39%). The clinical burden of food allergies were found to be greater in patients with multiple food allergies, and different for adults versus pediatric patients.
UNASSIGNED: This is the first study to assess patient experience and disease burden information from patients contributing to the FARE Patient Registry, thus providing a unique insight into the lives of patients in the United States with food allergies. These insights may assist clinicians and other public health stakeholders in the management of patients with food allergies.
摘要：
■食物过敏是严重的，可能危及生命，经常给病人和他们的照顾者带来很大的负担，包括对生活质量的影响。
■为了评估食物过敏的真实世界患者负担，使用食物过敏研究与教育（FARE）患者登记处（NCT04653324）提供的自我报告数据。
FARE患者登记处是自愿的，可以捕获美国成年人和儿科患者的真实经历，和他们的照顾者，通过一系列评估患者健康状况和食物过敏经历的调查。对自我报告的数据进行描述性分析。
■FARE研究队列包括5587名食物过敏患者；82%有多种食物过敏，62%年龄<18岁。大约一半的患者最初是由过敏症/免疫学家诊断的（53％）。最常见的是皮肤点刺试验（71％）或血清免疫球蛋白E试验（62％）。这项分析发现，食物过敏(最常见的是花生[66%]，树坚果[61%]，鸡蛋[43%]，和牛奶[37%])给患者带来了巨大的临床负担，其中许多人经历与食物有关的过敏反应和合并症。许多患者每年经历1次以上的食物相关过敏反应（42%）。46%的人经历了食物引起的过敏反应。一半的食物相关过敏反应发生在家里。77％的患者经历了对食物过敏原的意外暴露。食物过敏患者报告的最常见的过敏性合并症是特应性皮炎（48％），哮喘（46%），和过敏性鼻炎（39%）。发现食物过敏的临床负担在患有多种食物过敏的患者中更大，成人与儿科患者不同。
这是第一项评估FARE患者登记处患者经验和疾病负担信息的研究，从而为美国食物过敏患者的生活提供了独特的见解。这些见解可以帮助临床医生和其他公共卫生利益相关者管理食物过敏患者。
■为了评估食物过敏的真实世界患者负担，使用食物过敏研究与教育（FARE）患者登记处（NCT04653324）提供的自我报告数据。
FARE患者登记处是自愿的，可以捕获美国成年人和儿科患者的真实经历，和他们的照顾者，通过一系列评估患者健康状况和食物过敏经历的调查。对自我报告的数据进行描述性分析。
■FARE研究队列包括5587名食物过敏患者；82%有多种食物过敏，62%年龄<18岁。大约一半的患者最初是由过敏症/免疫学家诊断的（53％）。最常见的是皮肤点刺试验（71％）或血清免疫球蛋白E试验（62％）。这项分析发现，食物过敏(最常见的是花生[66%]，树坚果[61%]，鸡蛋[43%]，和牛奶[37%])给患者带来了巨大的临床负担，其中许多人经历与食物有关的过敏反应和合并症。许多患者每年经历1次以上的食物相关过敏反应（42%）。46%的人经历了食物引起的过敏反应。一半的食物相关过敏反应发生在家里。77％的患者经历了对食物过敏原的意外暴露。食物过敏患者报告的最常见的过敏性合并症是特应性皮炎（48％），哮喘（46%），和过敏性鼻炎（39%）。发现食物过敏的临床负担在患有多种食物过敏的患者中更大，成人与儿科患者不同。
这是第一项评估FARE患者登记处患者经验和疾病负担信息的研究，从而为美国食物过敏患者的生活提供了独特的见解。这些见解可以帮助临床医生和其他公共卫生利益相关者管理食物过敏患者。
