Abstract：
Biomaterial-based drug-carrying systems have scored enormous focus in the biomedical sector. Poly(lactic acid) (PLA) is a versatile material in this context. A porous and hydrophilic PLA surface can do this job better. We aimed to synthesize pH-responsive PLA-based porous films for uptaking and releasing amikacin sulfate in the aqueous media. The native PLA lacks functional/polar sites for the said purpose. So, we tended to aminolyze it for tailored physicochemical and surface properties. The amino (-NH2) group density on the treated films was examined using the ninhydrin assay. Electron microscopic analyses indicated the retention of porous morphology after aminolysis. Surface wettability and FTIR results expressed that the resultant films became hydrophilic after aminolysis. The thermal analysis expressed reasonable thermal stability of the aminolyzed films. The prepared films expressed pH-responsive behaviour for loading and releasing amikacin sulfate drug at pH 5.5 and 7.4, respectively. The drug release data best-fitted the first-order kinetic model based on Akaike information and model selection criteria. The prepared PLA-based aminolyzed films qualified as potential candidates for pH-responsive drug delivery applications. This study could be the first report on pH-responsive amikacin sulfate uptake and release on the swellable aminolyzed PLA-based porous films for effective drug delivery application.
摘要：
基于生物材料的药物携带系统在生物医学领域得到了极大的关注。在这种情况下,聚(乳酸)(PLA)是通用材料。多孔和亲水的PLA表面可以更好地完成这项工作。我们旨在合成pH响应的PLA基多孔膜，用于在水介质中吸收和释放硫酸阿米卡星。天然PLA缺乏用于所述目的的功能/极性位点。所以,我们倾向于对其进行氨基分解以获得定制的物理化学和表面特性。使用九三酮测定法检查经处理的膜上的氨基(-NH2)基团密度。电子显微镜分析表明，氨解后保留了多孔形态。表面润湿性和FTIR结果表明，氨解后所得薄膜变得亲水。热分析表明了氨解膜的合理热稳定性。制备的薄膜分别在pH5.5和7.4时表现出pH响应性，可加载和释放硫酸阿米卡星药物。药物释放数据基于Akaike信息和模型选择标准最佳拟合了一级动力学模型。所制备的基于PLA的氨解膜符合作为pH响应性药物递送应用的潜在候选物的资格。这项研究可能是关于pH响应性硫酸阿米卡星在可溶胀的氨解PLA基多孔膜上吸收和释放的有效药物递送应用的首次报道。
