Abstract：
MicroRNAs (miRNAs) are a class of short non-coding RNAs that play a crucial role in regulating gene expression across multiple levels. They are involved in a wide range of physiological processes, including proliferation, differentiation, apoptosis, and cell cycle control. In recent years, miRNAs have emerged as pivotal regulatory molecules in the development and progression of tumors. Among these, miR-155 has garnered significant attention due to its high expression in various diseases, particularly urologic malignancies. Since an extensive corpus of studies having focused on the roles of miR-155 in various urologic malignancies, it is essential to summarize the current evidence on this topic through a comprehensive review. Altered miR-155 expression is related to various physiological and pathological processes, including immune response, inflammation, tumor development and treatment resistance. Notably, alterations in miR-155 expression have been observed in urologic malignancies as well. The up-regulation of miR-155 expression is commonly observed in urologic malignancies, contributing to their progression by targeting specific proteins and signaling pathways. This article provides a comprehensive review of the significant role played by miR-155 in the development of urologic malignancies. Furthermore, the potential of miR-155 as a biomarker and therapeutic target in urologic malignancies is also discussed.
摘要：
MicroRNAs(miRNA)是一类短的非编码RNA,在多个水平的基因表达调控中起着至关重要的作用。它们参与了广泛的生理过程，包括扩散，分化,凋亡，和细胞周期控制。近年来,miRNA已成为肿瘤发展和进展中的关键调控分子。其中,miR-155因其在各种疾病中的高表达而备受关注。尤其是泌尿系恶性肿瘤.由于广泛的研究集中在miR-155在各种泌尿系统恶性肿瘤中的作用，通过全面审查总结目前关于这一主题的证据是至关重要的。miR-155表达改变与多种生理和病理过程有关,包括免疫反应，炎症,肿瘤的发展和治疗抵抗。值得注意的是,在泌尿系恶性肿瘤中也观察到miR-155表达的改变.miR-155表达的上调通常在泌尿系恶性肿瘤中观察到，通过靶向特定的蛋白质和信号通路促进其进展。本文就miR-155在泌尿系恶性肿瘤发生发展中的重要作用作一综述。此外，还讨论了miR-155作为泌尿系恶性肿瘤生物标志物和治疗靶点的潜力.
