PDF(Pubmed)
Abstract：
OBJECTIVE: This integrative search aimed to provide a scoping overview of the relationships between the benefits and harms of alcohol drinking with cardiovascular events as associated to body fat mass and fatty liver diseases, as well as offering critical insights for precision nutrition research and personalized medicine implementation concerning cardiovascular risk management associated to ethanol consumption.
RESULTS: Frequent alcohol intake could contribute to a sustained rise in adiposity over time. Body fat distribution patterns (abdominal/gluteus-femoral) and intrahepatic accumulation of lipids have been linked to adverse cardiovascular clinical outcomes depending on ethanol intake. Therefore, there is a need to understand the complex interplay between alcohol consumption, adipose store distribution, metabolic dysfunction-associated steatotic liver disease (MASLD), and cardiovascular events in adult individuals. The current narrative review deals with underconsidered and apparently conflicting benefits concerning the amount of alcohol intake, ranging from abstention to moderation, and highlights the requirements for additional robust methodological studies and trials to interpret undertrained and existing controversies. The conclusion of this review emphasizes the need of newer multifaceted clinical approaches for precision medicine implementation, considering epidemiological strategies and pathophysiological mechanistic. Newer investigations and trials should be derived and performed particularly focusing both on alcohol\'s objective consequences as putatively mediated by fat deposition, including associated roles in fatty liver disease as well as to differentiate the impact of different levels of alcohol consumption (absence or moderation) concerning cardiovascular risks and accompanying clinical manifestations. Indeed, the threshold for the safe consumption of alcoholic drinks remains to be fully elucidated.
RESULTS: Frequent alcohol intake could contribute to a sustained rise in adiposity over time. Body fat distribution patterns (abdominal/gluteus-femoral) and intrahepatic accumulation of lipids have been linked to adverse cardiovascular clinical outcomes depending on ethanol intake. Therefore, there is a need to understand the complex interplay between alcohol consumption, adipose store distribution, metabolic dysfunction-associated steatotic liver disease (MASLD), and cardiovascular events in adult individuals. The current narrative review deals with underconsidered and apparently conflicting benefits concerning the amount of alcohol intake, ranging from abstention to moderation, and highlights the requirements for additional robust methodological studies and trials to interpret undertrained and existing controversies. The conclusion of this review emphasizes the need of newer multifaceted clinical approaches for precision medicine implementation, considering epidemiological strategies and pathophysiological mechanistic. Newer investigations and trials should be derived and performed particularly focusing both on alcohol\'s objective consequences as putatively mediated by fat deposition, including associated roles in fatty liver disease as well as to differentiate the impact of different levels of alcohol consumption (absence or moderation) concerning cardiovascular risks and accompanying clinical manifestations. Indeed, the threshold for the safe consumption of alcoholic drinks remains to be fully elucidated.
摘要：
目的：这项综合搜索旨在提供饮酒的益处和危害与体脂质量和脂肪肝疾病相关的心血管事件之间关系的范围概述。并为与乙醇消费相关的心血管风险管理提供精准营养研究和个性化医疗实施的关键见解。
结果：经常饮酒可能导致肥胖持续增加。身体脂肪分布模式（腹部/臀肌-股骨）和肝内脂质积累与乙醇摄入量相关的不良心血管临床结果。因此,有必要了解酒精消费之间复杂的相互作用，脂肪储存分布，代谢功能障碍相关的脂肪变性肝病（MASLD），和成人心血管事件。当前的叙述审查涉及关于酒精摄入量的考虑不足和明显冲突的好处，从弃权到温和，并强调了对其他可靠的方法学研究和试验的要求，以解释训练不足和现有的争议。这篇综述的结论强调了实施精准医学需要更新的多方面临床方法，考虑流行病学策略和病理生理机制。新的调查和试验应该得到和进行，特别是关注酒精的客观后果作为脂肪沉积的推定介导，包括在脂肪肝疾病中的相关作用，以及区分不同饮酒水平（缺乏或适度）对心血管风险和伴随临床表现的影响。的确,安全饮用酒精饮料的门槛仍有待完全阐明。
结果：经常饮酒可能导致肥胖持续增加。身体脂肪分布模式（腹部/臀肌-股骨）和肝内脂质积累与乙醇摄入量相关的不良心血管临床结果。因此,有必要了解酒精消费之间复杂的相互作用，脂肪储存分布，代谢功能障碍相关的脂肪变性肝病（MASLD），和成人心血管事件。当前的叙述审查涉及关于酒精摄入量的考虑不足和明显冲突的好处，从弃权到温和，并强调了对其他可靠的方法学研究和试验的要求，以解释训练不足和现有的争议。这篇综述的结论强调了实施精准医学需要更新的多方面临床方法，考虑流行病学策略和病理生理机制。新的调查和试验应该得到和进行，特别是关注酒精的客观后果作为脂肪沉积的推定介导，包括在脂肪肝疾病中的相关作用，以及区分不同饮酒水平（缺乏或适度）对心血管风险和伴随临床表现的影响。的确,安全饮用酒精饮料的门槛仍有待完全阐明。
