Abstract：
Trichomonas tenax is an oral protozoan with an estimated global pooled prevalence of 17% in the human population.1 Observational studies have demonstrated a significant statistical correlation between oral colonization by T. tenax and the progression of periodontal disease.2 Proposed pathogenic mechanisms for this protozoan include the production of tissue-damaging enzymes, induction of apoptosis in human cells, and dysbiosis of the oral microbiome.3 In patients for whom metronidazole (MTZ) is contraindicated, phytochemicals may offer a viable alternative for controlling T. tenax. Various plant extracts have shown promising in vitro activity against other trichomonads, such as T. vaginalis and Tritrichomonas foetus, as reviewed by Friedman et al.4.
摘要：
Tenax毛滴虫是一种口腔原生动物，在人类中的全球合并患病率估计为17％。1观察性研究表明，Tenax的口腔定植与牙周病的进展之间存在显着的统计相关性。2该原生动物的拟议致病机制包括组织损伤酶的产生，诱导人细胞凋亡，和口腔微生物菌群失调。3在甲硝唑（MTZ）禁忌的患者中，植物化学物质可能为控制T.tenax提供可行的替代方法。各种植物提取物对其他滴虫显示出有希望的体外活性，例如阴道毛虫和Tritrichomonas胎儿，由弗里德曼等人审查。4.
