Abstract：
Fusarium species are an increasingly important cause of meningitis and invasive disease in immunocompromised patients as well as in otherwise healthy patients as observed in two recent healthcare-associated outbreaks. This review summarizes recently published information on treatment and diagnosis of this infection.
Incidence of Fusarium species meningitis and invasive fusariosis are increasing. Molecular techniques are improving the speed of diagnosis. New antifungal agents in development show good in vitro activity against some Fusarium species. New technologies, including cerebrospinal fluid (CSF) filtration, may play a role in treatment of central nervous system (CNS) disease. Due to the continued prime importance of the host immune system in recovery, immunomodulatory treatments may play a role in treatment.
The overall incidence of CNS fusariosis is increasing with a continued poor prognosis, but new diagnostic and treatment modalities are in development which may offer improvements.
Incidence of Fusarium species meningitis and invasive fusariosis are increasing. Molecular techniques are improving the speed of diagnosis. New antifungal agents in development show good in vitro activity against some Fusarium species. New technologies, including cerebrospinal fluid (CSF) filtration, may play a role in treatment of central nervous system (CNS) disease. Due to the continued prime importance of the host immune system in recovery, immunomodulatory treatments may play a role in treatment.
The overall incidence of CNS fusariosis is increasing with a continued poor prognosis, but new diagnostic and treatment modalities are in development which may offer improvements.
摘要：
目的：镰刀菌是免疫功能低下患者以及其他健康患者中脑膜炎和侵袭性疾病的一个日益重要的原因，如最近两次与医疗保健相关的疫情中所观察到的。这篇综述总结了最近发表的有关这种感染的治疗和诊断的信息。
结果：镰刀菌脑膜炎和侵袭性镰刀菌病的发病率正在增加。分子技术正在提高诊断速度。开发中的新抗真菌剂对某些镰刀菌物种显示出良好的体外活性。新技术,包括脑脊液（CSF）过滤，可能在中枢神经系统（CNS）疾病的治疗中发挥作用。由于宿主免疫系统在恢复中的持续重要性，免疫调节治疗可能在治疗中起作用。
结论：中枢神经系统镰刀菌病的总体发病率随着持续不良预后而增加，但新的诊断和治疗模式正在开发中，可能会提供改进。
结果：镰刀菌脑膜炎和侵袭性镰刀菌病的发病率正在增加。分子技术正在提高诊断速度。开发中的新抗真菌剂对某些镰刀菌物种显示出良好的体外活性。新技术,包括脑脊液（CSF）过滤，可能在中枢神经系统（CNS）疾病的治疗中发挥作用。由于宿主免疫系统在恢复中的持续重要性，免疫调节治疗可能在治疗中起作用。
结论：中枢神经系统镰刀菌病的总体发病率随着持续不良预后而增加，但新的诊断和治疗模式正在开发中，可能会提供改进。
