PDF(Pubmed)
Abstract：
Pathergy test indicates nonspecific hyper-reactivity of the skin to aseptic trauma in Behçet syndrome (BS) and is considered as an adjunctive diagnostic test with a good specificity albeit with low sensitivity. We tested the hypothesis that a relationship exists between active clinical manifestations of BS and the pathergy-positivity when performed simultaneously. Pathergy test and detailed dermatologic examination were done in 105 BS patients (60M/45F); who were seen consecutively at the multi-disciplinary BS outpatient clinic in a single tertiary center. Information regarding demographic and clinical characteristics, pathergy test results at diagnosis, and details about treatment were obtained from patient charts. Disease activity was assessed using Behçet Disease Current Activity Form. Among 105 patients, 27 (25.7%) were pathergy-positive at the time of the study visit whereas 40.9% were pathergy-positive at the time of the diagnosis. There was no relation between pathergy test and patient age or disease duration, either. Pathergy-positivity was significantly more common in patients with folliculitis compared to those without folliculitis (40.7% vs 19.2%; P = .026). The test was also positive in all 3 patients with leg ulcers due to venous stasis. We found that among all skin-mucosa lesions only the presence of folliculitis was associated with pathergy positivity with statistical significance. It was also remarkable that the current pathergy was positive in all 3 patients with active leg ulcers but this finding warrants further studies because of the low patient numbers.
摘要：
Pathergy测试表明Behçet综合征（BS）中皮肤对无菌性创伤的非特异性高反应性，尽管敏感性低，但仍被认为是具有良好特异性的辅助诊断测试。我们检验了以下假设：同时进行时，BS的活跃临床表现与动脉阳性之间存在关系。对105例BS患者（60M/45F）进行了动脉粥样硬化测试和详细的皮肤病学检查；他们在一个三级中心的多学科BS门诊诊所连续就诊。有关人口统计学和临床特征的信息，诊断时的pathergy测试结果，有关治疗的详细信息来自患者图表。使用Behçet疾病当前活动表评估疾病活动。在105名患者中，27（25.7％）在研究访问时呈动脉粥样硬化阳性，而40.9％在诊断时呈动脉粥样硬化阳性。pathergy测试与患者年龄或疾病持续时间之间没有关系，要么。与没有毛囊炎的患者相比，毛囊炎患者的动脉粥样硬化阳性明显更常见（40.7％vs19.2％；P=0.026）。在所有3例因静脉淤滞引起的腿部溃疡的患者中，测试也呈阳性。我们发现，在所有皮肤粘膜病变中，只有毛囊炎的存在与动脉粥样硬化阳性相关，具有统计学意义。同样值得注意的是，所有3例活动性腿部溃疡患者的当前病变均为阳性，但由于患者人数少，这一发现值得进一步研究。
