PDF(Pubmed)
Abstract：
Treatment with immune checkpoint inhibitors is effective in various cancers, but may be associated with immune-mediated side effects in other organs. Among the more common ones is gastrointestinal tract involvement, especially colitis. In most patients, colitis is mild or responds to corticosteroid treatment. A smaller proportion of patients, more often those treated with cytotoxic T lymphocyte antigen-4 inhibitors, may have a more severe course of colitis, even life-threatening complications. In these patients, prompt action, timely diagnosis with endoscopic evaluation and early treatment with high-dose corticosteroids and, if ineffective, rescue therapy with biologic agents such as infliximab and vedolizumab are needed. We present three cases from our clinical practice, data on incidence and clinical presentation, current recommendations regarding diagnostic approach and treatment of immune checkpoint inhibitors induced colitis.
摘要：
用免疫检查点抑制剂治疗对各种癌症有效，但可能与其他器官的免疫介导的副作用有关。其中更常见的是胃肠道受累，尤其是结肠炎.在大多数患者中，结肠炎是轻度的或对皮质类固醇治疗有反应。患者比例较小，更常见的是那些用细胞毒性T淋巴细胞抗原-4抑制剂治疗，可能有更严重的结肠炎病程，甚至危及生命的并发症.在这些患者中,迅速行动,及时诊断与内镜评估和早期治疗与大剂量糖皮质激素，如果无效，需要使用生物制剂如英夫利昔单抗和维多珠单抗进行抢救治疗.我们从临床实践中介绍了三个案例，关于发病率和临床表现的数据，关于免疫检查点抑制剂诱导的结肠炎的诊断方法和治疗的最新建议。
