Abstract：
UNASSIGNED: People with Huntington\'s disease (HD) exhibit neurocognitive alterations throughout the disease, including deficits in social cognitive processes such as Theory of Mind (ToM).
UNASSIGNED: The aim is to identify methodologies and ToM instruments employed in HD, alongside relevant findings, within the scientific literature of the past two decades.
UNASSIGNED: We conducted a comprehensive search for relevant papers in the SCOPUS, PubMed, APA-PsyArticles, Web of Science, Redalyc, and SciELO databases. In the selection process, we specifically focused on studies that included individuals with a confirmed genetic status of HD and investigated ToM functioning in patients with and without motor symptoms. The systematic review followed the PRISMA protocol.
UNASSIGNED: A total of 27 papers were selected for this systematic review, covering the period from 2003 to 2023. The findings consistently indicate that ToM is globally affected in patients with manifest motor symptoms. In individuals without motor symptoms, impairments are focused on the affective dimensions of ToM.
UNASSIGNED: Based on our analysis, affective ToM could be considered a potential biomarker for HD. Therefore, it is recommended that ToM assessment be included as part of neuropsychological evaluation protocols in clinical settings. Suchinclusion could aid in the identification of early stages of the disease and provide new opportunities for treatment, particularly with emerging drugs like antisense oligomers. The Prospero registration number for this review is CRD42020209769.
UNASSIGNED: The aim is to identify methodologies and ToM instruments employed in HD, alongside relevant findings, within the scientific literature of the past two decades.
UNASSIGNED: We conducted a comprehensive search for relevant papers in the SCOPUS, PubMed, APA-PsyArticles, Web of Science, Redalyc, and SciELO databases. In the selection process, we specifically focused on studies that included individuals with a confirmed genetic status of HD and investigated ToM functioning in patients with and without motor symptoms. The systematic review followed the PRISMA protocol.
UNASSIGNED: A total of 27 papers were selected for this systematic review, covering the period from 2003 to 2023. The findings consistently indicate that ToM is globally affected in patients with manifest motor symptoms. In individuals without motor symptoms, impairments are focused on the affective dimensions of ToM.
UNASSIGNED: Based on our analysis, affective ToM could be considered a potential biomarker for HD. Therefore, it is recommended that ToM assessment be included as part of neuropsychological evaluation protocols in clinical settings. Suchinclusion could aid in the identification of early stages of the disease and provide new opportunities for treatment, particularly with emerging drugs like antisense oligomers. The Prospero registration number for this review is CRD42020209769.
摘要：
■亨廷顿病（HD）患者在整个疾病中表现出神经认知改变，包括社会认知过程中的缺陷，如心理理论(ToM)。
■目的是确定HD中使用的方法和ToM仪器，除了相关发现，在过去二十年的科学文献中。
■我们对SCOPUS中的相关论文进行了全面搜索，PubMed,APA-PsyArticles,WebofScience,Redalyc,和SciELO数据库。在选择过程中，我们特别关注的研究包括具有已确认的HD遗传状态的个体,并调查了有或无运动症状的患者的ToM功能.系统评价遵循PRISMA方案。
■本次系统综述共选取了27篇论文，涵盖2003年至2023年期间。研究结果一致表明，在具有明显运动症状的患者中，ToM受到全球影响。在没有运动症状的个体中，损伤集中在ToM的情感维度上。
■根据我们的分析，情感ToM可以被认为是HD的潜在生物标志物。因此,建议将ToM评估作为临床环境中神经心理学评估方案的一部分.这种纳入可以帮助识别疾病的早期阶段，并提供新的治疗机会，特别是反义寡聚体等新兴药物。本次审查的Prospero注册号为CRD42020209769。
■目的是确定HD中使用的方法和ToM仪器，除了相关发现，在过去二十年的科学文献中。
■我们对SCOPUS中的相关论文进行了全面搜索，PubMed,APA-PsyArticles,WebofScience,Redalyc,和SciELO数据库。在选择过程中，我们特别关注的研究包括具有已确认的HD遗传状态的个体,并调查了有或无运动症状的患者的ToM功能.系统评价遵循PRISMA方案。
■本次系统综述共选取了27篇论文，涵盖2003年至2023年期间。研究结果一致表明，在具有明显运动症状的患者中，ToM受到全球影响。在没有运动症状的个体中，损伤集中在ToM的情感维度上。
■根据我们的分析，情感ToM可以被认为是HD的潜在生物标志物。因此,建议将ToM评估作为临床环境中神经心理学评估方案的一部分.这种纳入可以帮助识别疾病的早期阶段，并提供新的治疗机会，特别是反义寡聚体等新兴药物。本次审查的Prospero注册号为CRD42020209769。
