PDF(Pubmed)
Abstract：
BACKGROUND: Sleep disturbances are a potentially modifiable risk factor for neurodegenerative dementia secondary to Alzheimer disease (AD) and Lewy body disease (LBD). Therefore, we need to identify the best methods to study sleep in this population.
OBJECTIVE: This study will assess the feasibility and acceptability of various wearable devices, smart devices, and remote study tasks in sleep and cognition research for people with AD and LBD.
METHODS: We will deliver a feasibility and acceptability study alongside a prospective observational cohort study assessing sleep and cognition longitudinally in the home environment. Adults aged older than 50 years who were diagnosed with mild to moderate dementia or mild cognitive impairment (MCI) due to probable AD or LBD and age-matched controls will be eligible. Exclusion criteria include lack of capacity to consent to research, other causes of MCI or dementia, and clinically significant sleep disorders. Participants will complete a cognitive assessment and questionnaires with a researcher and receive training and instructions for at-home study tasks across 8 weeks. At-home study tasks include remote sleep assessments using wearable devices (electroencephalography headband and actigraphy watch), app-based sleep diaries, online cognitive assessments, and saliva samples for melatonin- and cortisol-derived circadian markers. Feasibility outcomes will be assessed relating to recruitment and retention, data completeness, data quality, and support required. Feedback on acceptability and usability will be collected throughout the study period and end-of-study interviews will be analyzed using thematic analysis.
RESULTS: Recruitment started in February 2022. Data collection is ongoing, with final data expected in February 2024 and data analysis and publication of findings scheduled for the summer of 2024.
CONCLUSIONS: This study will allow us to assess if remote testing using smart devices and wearable technology is a viable alternative to traditional sleep measurements, such as polysomnography and questionnaires, in older adults with and without MCI or dementia due to AD or LBD. Understanding participant experience and the barriers and facilitators to technology use for research purposes and remote research in this population will assist with the development of, recruitment to, and retention within future research projects studying sleep and cognition outside of the clinic or laboratory.
UNASSIGNED: DERR1-10.2196/52652.
OBJECTIVE: This study will assess the feasibility and acceptability of various wearable devices, smart devices, and remote study tasks in sleep and cognition research for people with AD and LBD.
METHODS: We will deliver a feasibility and acceptability study alongside a prospective observational cohort study assessing sleep and cognition longitudinally in the home environment. Adults aged older than 50 years who were diagnosed with mild to moderate dementia or mild cognitive impairment (MCI) due to probable AD or LBD and age-matched controls will be eligible. Exclusion criteria include lack of capacity to consent to research, other causes of MCI or dementia, and clinically significant sleep disorders. Participants will complete a cognitive assessment and questionnaires with a researcher and receive training and instructions for at-home study tasks across 8 weeks. At-home study tasks include remote sleep assessments using wearable devices (electroencephalography headband and actigraphy watch), app-based sleep diaries, online cognitive assessments, and saliva samples for melatonin- and cortisol-derived circadian markers. Feasibility outcomes will be assessed relating to recruitment and retention, data completeness, data quality, and support required. Feedback on acceptability and usability will be collected throughout the study period and end-of-study interviews will be analyzed using thematic analysis.
RESULTS: Recruitment started in February 2022. Data collection is ongoing, with final data expected in February 2024 and data analysis and publication of findings scheduled for the summer of 2024.
CONCLUSIONS: This study will allow us to assess if remote testing using smart devices and wearable technology is a viable alternative to traditional sleep measurements, such as polysomnography and questionnaires, in older adults with and without MCI or dementia due to AD or LBD. Understanding participant experience and the barriers and facilitators to technology use for research purposes and remote research in this population will assist with the development of, recruitment to, and retention within future research projects studying sleep and cognition outside of the clinic or laboratory.
UNASSIGNED: DERR1-10.2196/52652.
摘要：
背景：睡眠障碍是阿尔茨海默病（AD）和路易体病（LBD）继发的神经退行性痴呆的潜在可改变的危险因素。因此,我们需要找出研究该人群睡眠的最佳方法。
目的：本研究将评估各种可穿戴设备的可行性和可接受性，智能设备，以及AD和LBD患者睡眠和认知研究中的远程研究任务。
方法：我们将提供一项可行性和可接受性研究，以及一项前瞻性观察性队列研究，评估家庭环境中的睡眠和认知纵向。年龄超过50岁的成年人，由于可能的AD或LBD而被诊断为轻度至中度痴呆或轻度认知障碍（MCI），并且年龄匹配的对照将符合资格。排除标准包括缺乏同意研究的能力，MCI或痴呆的其他原因，和临床上显著的睡眠障碍。参与者将与研究人员一起完成认知评估和问卷调查，并在8周内接受家庭研究任务的培训和指导。家庭研究任务包括使用可穿戴设备（脑电图头带和活动记录手表）进行远程睡眠评估，基于应用程序的睡眠日记，在线认知评估，和唾液样本中的褪黑激素和皮质醇衍生的昼夜节律标记。将评估与招聘和保留有关的可行性结果，数据完整性，数据质量，需要的支持。关于可接受性和可用性的反馈将在整个研究期间收集，研究结束访谈将使用主题分析进行分析。
结果：招聘始于2022年2月。数据收集正在进行中，最终数据预计将于2024年2月发布，数据分析和调查结果将于2024年夏季发布。
结论：这项研究将使我们能够评估使用智能设备和可穿戴技术的远程测试是否是传统睡眠测量的可行替代方案，如多导睡眠图和问卷调查，在患有和不患有由AD或LBD引起的MCI或痴呆的老年人中。了解参与者的经验以及在该人群中用于研究目的和远程研究的技术使用的障碍和促进者将有助于发展，招募,并保留在未来的研究项目中，研究诊所或实验室以外的睡眠和认知。
■DERR1-10.2196/52652。
目的：本研究将评估各种可穿戴设备的可行性和可接受性，智能设备，以及AD和LBD患者睡眠和认知研究中的远程研究任务。
方法：我们将提供一项可行性和可接受性研究，以及一项前瞻性观察性队列研究，评估家庭环境中的睡眠和认知纵向。年龄超过50岁的成年人，由于可能的AD或LBD而被诊断为轻度至中度痴呆或轻度认知障碍（MCI），并且年龄匹配的对照将符合资格。排除标准包括缺乏同意研究的能力，MCI或痴呆的其他原因，和临床上显著的睡眠障碍。参与者将与研究人员一起完成认知评估和问卷调查，并在8周内接受家庭研究任务的培训和指导。家庭研究任务包括使用可穿戴设备（脑电图头带和活动记录手表）进行远程睡眠评估，基于应用程序的睡眠日记，在线认知评估，和唾液样本中的褪黑激素和皮质醇衍生的昼夜节律标记。将评估与招聘和保留有关的可行性结果，数据完整性，数据质量，需要的支持。关于可接受性和可用性的反馈将在整个研究期间收集，研究结束访谈将使用主题分析进行分析。
结果：招聘始于2022年2月。数据收集正在进行中，最终数据预计将于2024年2月发布，数据分析和调查结果将于2024年夏季发布。
结论：这项研究将使我们能够评估使用智能设备和可穿戴技术的远程测试是否是传统睡眠测量的可行替代方案，如多导睡眠图和问卷调查，在患有和不患有由AD或LBD引起的MCI或痴呆的老年人中。了解参与者的经验以及在该人群中用于研究目的和远程研究的技术使用的障碍和促进者将有助于发展，招募,并保留在未来的研究项目中，研究诊所或实验室以外的睡眠和认知。
■DERR1-10.2196/52652。
