PDF(Pubmed)
Abstract：
Canonical retinoid signaling via nuclear receptors and gene regulation is critical for the initiation of developmental processes such as cellular differentiation, patterning and neurite outgrowth, but also mediates nerve regeneration and synaptic functions in adult nervous systems. In addition to canonical transcriptional regulation, retinoids also exert rapid effects, and there are now multiple lines of evidence supporting non-canonical retinoid actions outside of the nucleus, including in dendrites and axons. Together, canonical and non-canonical retinoid signaling provide the precise temporal and spatial control necessary to achieve the fine cellular coordination required for proper nervous system function. Here, we examine and discuss the evidence supporting non-canonical actions of retinoids in neural development and regeneration as well as synaptic function, including a review of the proposed molecular mechanisms involved.
摘要：
典型的类维生素A信号通过核受体和基因调控是启动发育过程如细胞分化的关键,图案形成和神经突生长，而且还介导成人神经系统的神经再生和突触功能。除了规范的转录调控，类维生素A也发挥快速作用，现在有多条证据支持细胞核外的非规范类维生素A作用，包括树突和轴突。一起,规范和非规范的类维生素A信号提供了精确的时间和空间控制，以实现适当的神经系统功能所需的精细细胞协调。这里,我们研究并讨论了支持类维生素A在神经发育和再生以及突触功能中的非规范作用的证据，包括对拟议的分子机制的审查。
