PDF(Pubmed)
Abstract：
Hyperuricemia (HUA), a severe metabolic disease derived from purine metabolism disorder, will lead to abnormally increased serum uric acid (SUA) levels in the body. Studies have shown that HUA is highly related to gout, hypertension, diabetes, coronary heart disease, chronic kidney diseases, and so on. Traditional Chinese medicine (TCM) shows excellent results in treating HUA because of its unique advantages of multi-metabolites and multi-targets. This article reports on the use of TCM components for uric acid (UA)-lowering activity with excellent efficacy and low side effects based on established HUA models. This work summarizes the advantages and limitations of various HUA disease models for efficacy evaluation. Applications of TCM in HUA treatment have also been discussed in detail. This paper reveals recent research progress on HUA in constructing evaluation models and systematic TCM interventions. It will provide a scientific reference for establishing the HUA model and suggest future TCM-related HUA studies.
摘要：
高尿酸血症(HUA),由嘌呤代谢紊乱引起的严重代谢疾病,会导致体内血清尿酸（SUA）水平异常升高。研究表明，HUA与痛风高度相关，高血压,糖尿病,冠心病,慢性肾脏疾病,等等。中药因其独特的多代谢产物、多靶点优势,在治疗HUA方面表现出优异的效果。本文报道了在建立HUA模型的基础上，使用中药成分进行降尿酸（UA）活性，具有优异的疗效和低副作用。这项工作总结了各种HUA疾病模型用于疗效评估的优点和局限性。对中医药在HUA治疗中的应用也进行了详细的讨论。本文揭示了HUA在构建评价模型和系统的中医干预方面的最新研究进展。这将为HUA模型的建立提供科学依据，并为未来中医药相关HUA研究提供建议。
