PDF(Pubmed)
Abstract：
Globally, millions of individuals are impacted by neurodegenerative disorders including Huntington\'s disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson\'s disease (PD), and Alzheimer\'s disease (AD). Although a great deal of energy and financial resources have been invested in disease-related research, breakthroughs in therapeutic approaches remain elusive. The breakdown of cells usually happens together with the onset of neurodegenerative diseases. However, the mechanism that triggers neuronal loss is unknown. Lipid peroxidation, which is iron-dependent, causes a specific type of cell death called ferroptosis, and there is evidence its involvement in the pathogenic cascade of neurodegenerative diseases. However, the specific mechanisms are still not well known. The present article highlights the basic processes that underlie ferroptosis and the corresponding signaling networks. Furthermore, it provides an overview and discussion of current research on the role of ferroptosis across a variety of neurodegenerative conditions.
摘要：
全球范围内,数百万人受到包括亨廷顿病（HD）在内的神经退行性疾病的影响，肌萎缩侧索硬化(ALS),帕金森病（PD），和阿尔茨海默病（AD）。尽管在疾病相关研究上投入了大量的精力和财力,治疗方法的突破仍然难以捉摸。细胞的分解通常与神经退行性疾病的发作一起发生。然而,引发神经元丢失的机制尚不清楚。脂质过氧化,它依赖铁，导致一种特殊类型的细胞死亡，称为铁性死亡，有证据表明它参与了神经退行性疾病的致病级联反应。然而,具体机制尚不清楚。本文重点介绍了铁中毒的基本过程以及相应的信令网络。此外，它提供了有关铁性凋亡在各种神经退行性疾病中的作用的当前研究的概述和讨论。
