PDF(Pubmed)
Abstract：
UNASSIGNED: This review aims to conduct a comprehensive study of the diagnostic accuracy of interleukin-6 (IL-6) for multiple diseases by utilizing existing systematic reviews and meta-analyses.
UNASSIGNED: We performed a thorough search of Embase, Web of Science, PubMed, and Cochrane Database of Systematic Reviews up to April 2023 to gather meta-analyses that investigate the diagnostic accuracy of IL-6. To assess the methodological quality of the studies, we employed the Assessing the Methodological Quality of Systematic Reviews-2 and Grading of Recommendations, Assessment, Development and Evaluation criteria.
UNASSIGNED: We included 34 meta-analyses out of the 3024 articles retrieved from the search. These meta-analyses covered 9 categories of diseases of the International Classification of Diseases-11. Studies rated as \"Critically Low\" or \"Very Low\" in the quality assessment process were excluded, resulting in a total of 6 meta-analyses that encompassed sepsis, colorectal cancer, tuberculous pleural effusion (TPE), endometriosis, among others. Among these diseases, IL-6 demonstrated a relatively high diagnostic potential in accurately identifying TPE and endometriosis.
UNASSIGNED: IL-6 exhibited favorable diagnostic accuracy across multiple diseases, suggesting its potential as a reliable diagnostic biomarker in the near future. Substantial evidence supported its high diagnostic accuracy, particularly in the cases of TPE and endometriosis.
UNASSIGNED: We performed a thorough search of Embase, Web of Science, PubMed, and Cochrane Database of Systematic Reviews up to April 2023 to gather meta-analyses that investigate the diagnostic accuracy of IL-6. To assess the methodological quality of the studies, we employed the Assessing the Methodological Quality of Systematic Reviews-2 and Grading of Recommendations, Assessment, Development and Evaluation criteria.
UNASSIGNED: We included 34 meta-analyses out of the 3024 articles retrieved from the search. These meta-analyses covered 9 categories of diseases of the International Classification of Diseases-11. Studies rated as \"Critically Low\" or \"Very Low\" in the quality assessment process were excluded, resulting in a total of 6 meta-analyses that encompassed sepsis, colorectal cancer, tuberculous pleural effusion (TPE), endometriosis, among others. Among these diseases, IL-6 demonstrated a relatively high diagnostic potential in accurately identifying TPE and endometriosis.
UNASSIGNED: IL-6 exhibited favorable diagnostic accuracy across multiple diseases, suggesting its potential as a reliable diagnostic biomarker in the near future. Substantial evidence supported its high diagnostic accuracy, particularly in the cases of TPE and endometriosis.
摘要：
■本综述旨在通过利用现有的系统综述和荟萃分析，对白介素-6（IL-6）对多种疾病的诊断准确性进行全面研究。
■我们对Embase进行了彻底的搜索，WebofScience,PubMed,和截至2023年4月的Cochrane系统评价数据库，以收集调查IL-6诊断准确性的荟萃分析。为了评估研究的方法学质量，我们采用了评估系统评价的方法论质量-2和建议分级，评估,开发和评估标准。
■我们从搜索中检索到的3024篇文章中包含了34篇荟萃分析。这些荟萃分析涵盖了国际疾病分类11的9类疾病。在质量评估过程中被评为“严重低”或“非常低”的研究被排除在外，导致总共6个荟萃分析，包括脓毒症，结直肠癌,结核性胸腔积液(TPE),子宫内膜异位症,在其他人中。在这些疾病中,IL-6在准确识别TPE和子宫内膜异位症方面显示出相对较高的诊断潜力。
■IL-6在多种疾病中表现出良好的诊断准确性，表明其在不久的将来作为可靠的诊断生物标志物的潜力。大量证据支持它的高诊断准确性，特别是在TPE和子宫内膜异位症的病例中。
■我们对Embase进行了彻底的搜索，WebofScience,PubMed,和截至2023年4月的Cochrane系统评价数据库，以收集调查IL-6诊断准确性的荟萃分析。为了评估研究的方法学质量，我们采用了评估系统评价的方法论质量-2和建议分级，评估,开发和评估标准。
■我们从搜索中检索到的3024篇文章中包含了34篇荟萃分析。这些荟萃分析涵盖了国际疾病分类11的9类疾病。在质量评估过程中被评为“严重低”或“非常低”的研究被排除在外，导致总共6个荟萃分析，包括脓毒症，结直肠癌,结核性胸腔积液(TPE),子宫内膜异位症,在其他人中。在这些疾病中,IL-6在准确识别TPE和子宫内膜异位症方面显示出相对较高的诊断潜力。
■IL-6在多种疾病中表现出良好的诊断准确性，表明其在不久的将来作为可靠的诊断生物标志物的潜力。大量证据支持它的高诊断准确性，特别是在TPE和子宫内膜异位症的病例中。
