Abstract：
OBJECTIVE: This study aimed to apply diffusion-weighted imaging to the evaluation of cervical lymph nodes affected by medication-related osteonecrosis of the jaw (MRONJ).
METHODS: This retrospective study analysed the diffusion-weighted imaging data of 70 patients with or without MRONJ (Stages 0-3). The mean apparent diffusion coefficient (ADC) values of the submandibular (level IB) and superior internal jugular (level IIA) nodes in the control and MRONJ groups were calculated, and differences were analysed using the Mann-Whitney test. Moreover, receiver operating characteristic (ROC) curve analysis was performed to evaluate the ability of ADC values to predict lymph nodes that were affected by MRONJ. p < 0.05 was considered statistically significant.
RESULTS: The median [interquartile range] (×10-3 mm2/s) of level IB was 0.74 [0.7-0.81] and 0.93 [0.84-1.09] and that of level IIA was 0.79 [0.76-0.85] and 0.97 [0.84-1.06] in the control and MRONJ groups respectively. ROC analysis revealed that the ADC value had excellent ability to discriminate between the control and MRONJ groups.
CONCLUSIONS: The study findings indicate that diffusion-weighted imaging can contribute to differentiation of MRONJ from other cervical lymph node diseases and facilitate early detection of MRONJ.
METHODS: This retrospective study analysed the diffusion-weighted imaging data of 70 patients with or without MRONJ (Stages 0-3). The mean apparent diffusion coefficient (ADC) values of the submandibular (level IB) and superior internal jugular (level IIA) nodes in the control and MRONJ groups were calculated, and differences were analysed using the Mann-Whitney test. Moreover, receiver operating characteristic (ROC) curve analysis was performed to evaluate the ability of ADC values to predict lymph nodes that were affected by MRONJ. p < 0.05 was considered statistically significant.
RESULTS: The median [interquartile range] (×10-3 mm2/s) of level IB was 0.74 [0.7-0.81] and 0.93 [0.84-1.09] and that of level IIA was 0.79 [0.76-0.85] and 0.97 [0.84-1.06] in the control and MRONJ groups respectively. ROC analysis revealed that the ADC value had excellent ability to discriminate between the control and MRONJ groups.
CONCLUSIONS: The study findings indicate that diffusion-weighted imaging can contribute to differentiation of MRONJ from other cervical lymph node diseases and facilitate early detection of MRONJ.
摘要：
目的：本研究旨在将弥散加权成像应用于评估药物相关性颌骨坏死（MRONJ）影响的颈淋巴结。
方法：本回顾性研究分析了70例伴或不伴MRONJ（0-3期）患者的弥散加权成像数据。计算对照组和MRONJ组的下颌下（IB级）和颈内上（IIA级）淋巴结的平均表观扩散系数（ADC）值，并使用Mann-Whitney检验分析差异。此外，进行受试者工作特征(ROC)曲线分析,以评估ADC值预测受MRONJ影响的淋巴结的能力.p<0.05被认为是统计学上显著的。
结果：在对照组和MRONJ组中，IB水平的中位数[四分位距]（×10-3mm2/s）为0.74[0.7-0.81]和0.93[0.84-1.09]，而IIA水平的中位数为0.79[0.76-0.85]和0.97[0.84-1.06]。ROC分析显示，ADC值具有出色的区分对照组和MRONJ组的能力。
结论：研究结果表明，弥散加权成像有助于MRONJ与其他颈淋巴结疾病的鉴别，有助于MRONJ的早期发现。
方法：本回顾性研究分析了70例伴或不伴MRONJ（0-3期）患者的弥散加权成像数据。计算对照组和MRONJ组的下颌下（IB级）和颈内上（IIA级）淋巴结的平均表观扩散系数（ADC）值，并使用Mann-Whitney检验分析差异。此外，进行受试者工作特征(ROC)曲线分析,以评估ADC值预测受MRONJ影响的淋巴结的能力.p<0.05被认为是统计学上显著的。
结果：在对照组和MRONJ组中，IB水平的中位数[四分位距]（×10-3mm2/s）为0.74[0.7-0.81]和0.93[0.84-1.09]，而IIA水平的中位数为0.79[0.76-0.85]和0.97[0.84-1.06]。ROC分析显示，ADC值具有出色的区分对照组和MRONJ组的能力。
结论：研究结果表明，弥散加权成像有助于MRONJ与其他颈淋巴结疾病的鉴别，有助于MRONJ的早期发现。
