METHODS: One hundred and sixty patients diagnosed with sudden sensorineural hearing loss and undergoing IT were assigned to four groups based on the type or concentration of steroids administered (Group DM5: 5 mg/ml Dexamethasone sodium phosphate; Group DM10: 10 mg/ml Dexamethasone sodium phosphate; Group MP: 40 mg/ml Methylprednisolone sodium succinate; Group BM: 4 mg/ml Betamethasone sodium phosphate). Each group comprised 40 patients, and all participants received IT six times. The study assessed and compared the degrees and duration of pain, dizziness, and tympanic membrane damage following IT. Patients were asked to report the pain they felt using the numeric rating scale (NRS).
RESULTS: NRS scores for pain after IT showed significant differences among the four groups (p < 0.001). The average NRS scores for pain in each group were as follows: Group DM5: 1.53 ± 1.04; Group DM10: 1.45 ± 1.30; Group MP: 4.33 ± 2.22; Group BM: 6.03 ± 1.46. The durations of pain after IT also exhibited significant differences among the four groups (p < 0.001), with the longest duration observed in Group MP at 31.93 ± 15.20 min.
CONCLUSIONS: Different types of steroids could lead to varying degrees of pain when used in IT. Betamethasone could cause the most severe pain, and methylprednisolone could result in the longest duration of pain.
方法:诊断为突发性感音神经性耳聋并接受IT的患者根据使用类固醇的类型或浓度分为四组(DM5组:5mg/ml地塞米松磷酸钠;DM10组:10mg/ml地塞米松磷酸钠;MP组:40mg/ml甲泼尼龙琥珀酸钠;BM组:4mg/ml乙米磷酸钠)。每组40名患者,所有参与者都收到了六次。该研究评估并比较了疼痛的程度和持续时间,头晕,和鼓膜损伤后。要求患者使用数字评定量表(NRS)报告他们感到的疼痛。
结果:四组患者IT后疼痛的NRS评分有显著差异(p<0.001)。各组疼痛的平均NRS评分如下:DM5组:1.53±1.04;DM10组:1.45±1.30;MP组:4.33±2.22;BM组:6.03±1.46。IT后疼痛的持续时间在四组之间也表现出显着差异(p<0.001),在MP组中观察到的最长持续时间为31.93±15.20分钟。
结论:不同类型的类固醇用于IT时会导致不同程度的疼痛。倍他米松可引起最严重的疼痛,甲基强的松龙可能导致最长的疼痛持续时间。