PDF(Pubmed)
Abstract：
UNASSIGNED: Onychocytic matricoma (OCM) is a benign neoplasm of the nail matrix. Only 18 cases of this tumor have been reported in the literature to date. We retrospectively analyzed the clinical features of 14 patients with OCM. The most common clinical feature was longitudinal xanthopachyonychia (n = 9), followed by longitudinal leukopachyonychia (=3) and longitudinal pachymelanonychia (n = 2). The most common clinical findings identified following dermoscopy and analysis at high magnification of classical photographs were free-edge thickening of the nail plate without pitting (n = 14), longitudinal ridging (n = 7), round white clods (n = 7), white dots (n = 7), and filiform hemorrhages (n = 7), followed by oval and linear white clods (n = 5), fuzzy lateral border (n = 5), and red-purple blood clods (n = 3). Nail clipping histopathology showed a thickened nail plate with multiple, small, round-to-oval spaces. The tumor expressed immunopositivity for LEF-1. Dermoscopy of the nail plate and nail clipping histology provides useful information with regards to the differential diagnosis with subungual squamous cell carcinoma and nail melanoma. Ex vivo-in vivo correlation facilitates a better dermoscopic assessment of this unique underrecognized disease. However, the differential diagnosis between OCM and onychocytic carcinoma requires biopsy of the tumor. LEF-1 as an onychogenic marker can be used to resolve the differential diagnosis between OCM and subungual longitudinal acanthoma/seborrheic keratosis.
摘要：
■单核细胞基质瘤（OCM）是指甲基质的良性肿瘤。迄今为止，文献中仅报道了18例这种肿瘤。我们回顾性分析了14例OCM患者的临床特征。最常见的临床特征是纵向黄质甲（n=9），其次是纵向白质灰甲（=3）和纵向白质灰甲（n=2）。在皮肤镜检查和经典照片的高倍放大分析后发现的最常见的临床发现是指甲板的自由边缘增厚而没有凹陷（n=14），纵向起皱（n=7），圆形白色土块（n=7），白点（n=7），和丝状出血（n=7），其次是椭圆形和线性白色土块（n=5），模糊横向边界(n=5)，和红紫色血块（n=3）。剪指甲组织病理学显示指甲板增厚，有多个，小,圆形到椭圆形的空间。肿瘤对LEF-1表达免疫阳性。指甲板和指甲夹组织学的皮肤镜检查为甲下鳞状细胞癌和指甲黑色素瘤的鉴别诊断提供了有用的信息。离体-体内相关性有助于更好地评估这种独特的未被识别的疾病。然而,OCM与甲细胞癌的鉴别诊断需要肿瘤活检.LEF-1作为甲源性标志物可用于解决OCM与甲下纵行棘皮瘤/脂溢性角化病的鉴别诊断。
