Abstract：
UNASSIGNED: Forkhead box P3 (FoxP3) transcription factor plays critical roles in controlling immune responses and cancer progression in different cancers. FoxP3 expression within the tumor microenvironment (TME) may influence clinical outcomes negatively or positively, and it could play dual roles in cancer, either by promoting or inhibiting tumor development and progression. Some studies reported that high levels of FoxP3 could be associated with tumor progression and worse prognosis, while others reported contradictory results.
UNASSIGNED: In this special report, we present a brief account on the role and function of FoxP3 in the TME, and its contribution to the clinical outcomes of cancer patients. Importantly, we give insights on the potential factors that could contribute to different clinical outcomes in cancer patients.
UNASSIGNED: Different studies showed that FoxP3 expression can be associated with bad prognoses in cancer patients. However, FoxP3 could have opposing roles by enhancing cancer progression or regression. Location and expression of FoxP3 in T cells or tumor cells can have different impacts on cancer prognoses. Different factors should be considered to establish FoxP3 as a more robust prognostic biomarker and a potential therapeutic target for enhancing anti-tumor immunity and improving clinical outcomes of cancer patients.
UNASSIGNED: In this special report, we present a brief account on the role and function of FoxP3 in the TME, and its contribution to the clinical outcomes of cancer patients. Importantly, we give insights on the potential factors that could contribute to different clinical outcomes in cancer patients.
UNASSIGNED: Different studies showed that FoxP3 expression can be associated with bad prognoses in cancer patients. However, FoxP3 could have opposing roles by enhancing cancer progression or regression. Location and expression of FoxP3 in T cells or tumor cells can have different impacts on cancer prognoses. Different factors should be considered to establish FoxP3 as a more robust prognostic biomarker and a potential therapeutic target for enhancing anti-tumor immunity and improving clinical outcomes of cancer patients.
摘要：
■叉头盒P3（FoxP3）转录因子在控制不同癌症的免疫反应和癌症进展中起关键作用。FoxP3在肿瘤微环境（TME）中的表达可能对临床结果产生负面或正面影响。它可以在癌症中扮演双重角色，通过促进或抑制肿瘤的发展和进展。一些研究报道，高水平的FoxP3可能与肿瘤进展和预后恶化有关。而其他人报告的结果相互矛盾。
■在本特别报告中，我们简要介绍了FoxP3在TME中的作用和功能，以及它对癌症患者临床结局的贡献。重要的是,我们提供了可能导致癌症患者不同临床结局的潜在因素的见解.
■不同的研究表明，FoxP3的表达可能与癌症患者的不良预后有关。然而,FoxP3可能通过增强癌症进展或消退而具有相反的作用。FoxP3在T细胞或肿瘤细胞中的定位和表达可对癌症预后产生不同的影响。应考虑不同的因素来建立FoxP3作为更可靠的预后生物标志物和增强抗肿瘤免疫力和改善癌症患者临床结果的潜在治疗靶标。
■在本特别报告中，我们简要介绍了FoxP3在TME中的作用和功能，以及它对癌症患者临床结局的贡献。重要的是,我们提供了可能导致癌症患者不同临床结局的潜在因素的见解.
■不同的研究表明，FoxP3的表达可能与癌症患者的不良预后有关。然而,FoxP3可能通过增强癌症进展或消退而具有相反的作用。FoxP3在T细胞或肿瘤细胞中的定位和表达可对癌症预后产生不同的影响。应考虑不同的因素来建立FoxP3作为更可靠的预后生物标志物和增强抗肿瘤免疫力和改善癌症患者临床结果的潜在治疗靶标。
