Abstract：
Measles inclusion-body encephalitis (MIBE) is rare, with insights largely from case studies. We systematically analyzed subacute Sclerosing Panencephalitis (SSPE) cases in immunocompromised patients, identifying distinctive clinical and neuroimaging features. These findings could facilitate MIBE diagnosis without the need for brain biopsies. Our systematic review on MIBE and HIV-related SSPE adhered to PRISMA guidelines and was registered with PROSPERO. We searched multiple databases and followed a detailed inclusion process with independent reviews and quality assessment. Data on patient demographics, clinical features, and outcomes were compiled. A review of 39 studies on 49 MIBE patients and 8 reports on HIV-positive SSPE patients was conducted. Acute lymphoblastic leukemia, HIV, organ transplants, and malignancies were common precursors to MIBE. Perinatal HIV was prevalent among SSPE cases. Seizures were the primary symptom in MIBE, often drug-resistant and progressing to status epilepticus or epilepsia partialis continua, whereas periodic myoclonus was universal in SSPE. Neuroimaging showed distinct patterns for each group, and histopathology confirmed measles virus presence in 39% of MIBE cases. MIBE patients typically progressed to coma and death. In conclusion, MIBE and SSPE in HIV-infected patients present with distinct clinical pictures but identical brain pathological abnormalities.
摘要：
麻疹包涵体脑炎（MIBE）很少见，主要来自案例研究的见解。我们系统分析了免疫功能低下患者的亚急性硬化性全脑炎（SSPE）病例，识别独特的临床和神经影像学特征。这些发现可以促进MIBE诊断，而无需进行脑活检。我们对MIBE和HIV相关SSPE的系统评价遵循PRISMA指南，并在PROSPERO注册。我们搜索了多个数据库，并遵循了详细的纳入过程，并进行了独立审查和质量评估。患者人口统计数据，临床特征,并编制了结果。对49例MIBE患者的39项研究和8例HIV阳性SSPE患者的报告进行了回顾。急性淋巴细胞白血病,艾滋病毒,器官移植,恶性肿瘤是MIBE的常见前体。围产期HIV在SSPE病例中普遍存在。癫痫发作是MIBE的主要症状，通常耐药并发展为癫痫持续状态或癫痫持续，而周期性肌阵挛性在SSPE中是普遍存在的。神经成像显示每组不同的模式，组织病理学证实39％的MIBE病例存在麻疹病毒。MIBE患者通常进展为昏迷和死亡。总之,HIV感染患者的MIBE和SSPE表现出不同的临床表现，但脑部病理异常相同。
