Abstract：
Bone defects are a common complication of bone diseases, which often affect the quality of life and mental health of patients. The use of biomimetic bone scaffolds loaded with bioactive substances has become a focal point in the research on bone defect repair. In this study, composite scaffolds resembling bone tissue were created using nacre powder (NP) and sodium alginate (SA) through 3D printing. These scaffolds exhibit several physiological structural and mechanical characteristics of bone tissue, such as suitable porosity, an appropriate pore size, applicable degradation performance and satisfying the mechanical requirements of cancellous bone, etc. Then, platelet-rich fibrin (PRF), containing a mass of growth factors, was loaded on the NP/SA scaffolds. This was aimed to fully maximize the synergistic effect with NP, thereby accelerating bone tissue regeneration. Overall, this study marks the first instance of preparing a bionic bone structure scaffold containing NP by 3D printing technology, which is combined with PRF to further accelerate bone regeneration. These findings offer a new treatment strategy for bone tissue regeneration in clinical applications.
摘要：
骨缺损是骨病常见的并发症,这往往会影响患者的生活质量和心理健康。应用负载生物活性物质的仿生骨支架已成为骨缺损修复研究的热点。在这项研究中,使用珍珠质粉末（NP）和海藻酸钠（SA）通过3D打印创建类似骨组织的复合支架。这些支架表现出骨组织的一些生理结构和机械特性，例如合适的孔隙率，适当的孔径，适用的降解性能，满足松质骨的力学要求，等。然后，富血小板纤维蛋白(PRF),含有大量的生长因子，加载在NP/SA支架上。这旨在充分最大化与NP的协同效应，从而加速骨组织再生。总的来说,本研究标志着首次利用3D打印技术制备含有NP的仿生骨结构支架,与PRF结合以进一步加速骨再生。这些发现为临床应用中的骨组织再生提供了新的治疗策略。
