Abstract：
UNASSIGNED: Studies assessing the benefits of outpatient parenteral antimicrobial therapy (OPAT) have paid less attention to patient-centered factors such as patients\' experiences and their health-related quality of life (HRQoL).
UNASSIGNED: Prospective before-and-after quasi-experimental study enrolled adult patients receiving OPAT at a tertiary hospital in Derbyshire, UK, between October 2022 and October 2023. Consenting patients completed paired EQ-5D-3 L questionnaires before OPAT initiation and upon completion of therapy or 30 days after its commencement (whichever occurred first). Changes and predictors of change in HRQoL indicators and associations with clinical outcomes (treatment failure, adverse events, and 30-day unplanned readmission) were examined.
UNASSIGNED: Health state index and visual analogue scale (EQ VAS) scores of 162 enrolled patients at baseline were significantly lower than the UK population averages, but the patients experienced significant improvements in both scores and in four EQ-5D dimensions (mobility, self-care, usual activities, and pain/discomfort). Baseline health index and EQ VAS scores were significant independent predictors of positive changes in HRQoL scores.
UNASSIGNED: OPAT is associated with improved patient-reported quality of life and facilitates early return to work or school. Nevertheless, it is crucial to closely monitor patients with a lower baseline quality of life to optimize their overall OPAT experience.
UNASSIGNED: Prospective before-and-after quasi-experimental study enrolled adult patients receiving OPAT at a tertiary hospital in Derbyshire, UK, between October 2022 and October 2023. Consenting patients completed paired EQ-5D-3 L questionnaires before OPAT initiation and upon completion of therapy or 30 days after its commencement (whichever occurred first). Changes and predictors of change in HRQoL indicators and associations with clinical outcomes (treatment failure, adverse events, and 30-day unplanned readmission) were examined.
UNASSIGNED: Health state index and visual analogue scale (EQ VAS) scores of 162 enrolled patients at baseline were significantly lower than the UK population averages, but the patients experienced significant improvements in both scores and in four EQ-5D dimensions (mobility, self-care, usual activities, and pain/discomfort). Baseline health index and EQ VAS scores were significant independent predictors of positive changes in HRQoL scores.
UNASSIGNED: OPAT is associated with improved patient-reported quality of life and facilitates early return to work or school. Nevertheless, it is crucial to closely monitor patients with a lower baseline quality of life to optimize their overall OPAT experience.
摘要：
■评估门诊肠胃外抗菌治疗（OPAT）益处的研究较少关注以患者为中心的因素，例如患者的经历及其与健康相关的生活质量（HRQoL）。
■准实验研究前后的前瞻性研究招募了在德比郡一家三级医院接受OPAT的成年患者，英国,2022年10月至2023年10月。同意的患者在OPAT开始之前和治疗完成后或开始后30天（以先发生者为准）完成配对的EQ-5D-3L问卷。HRQoL指标变化的变化和预测因素以及与临床结果的关联(治疗失败，不良事件,和30天计划外再入院)进行了检查。
■162名入组患者在基线时的健康状况指数和视觉模拟量表（EQVAS）评分显着低于英国人口平均水平，但患者在得分和四个EQ-5D维度(移动性，自我照顾,平时的活动,和疼痛/不适)。基线健康指数和EQVAS评分是HRQoL评分正变化的重要独立预测因子。
OPAT与改善患者报告的生活质量有关，并有助于早日返回工作或学校。然而，密切监测基线生活质量较低的患者,以优化其整体OPAT体验至关重要.
■准实验研究前后的前瞻性研究招募了在德比郡一家三级医院接受OPAT的成年患者，英国,2022年10月至2023年10月。同意的患者在OPAT开始之前和治疗完成后或开始后30天（以先发生者为准）完成配对的EQ-5D-3L问卷。HRQoL指标变化的变化和预测因素以及与临床结果的关联(治疗失败，不良事件,和30天计划外再入院)进行了检查。
■162名入组患者在基线时的健康状况指数和视觉模拟量表（EQVAS）评分显着低于英国人口平均水平，但患者在得分和四个EQ-5D维度(移动性，自我照顾,平时的活动,和疼痛/不适)。基线健康指数和EQVAS评分是HRQoL评分正变化的重要独立预测因子。
OPAT与改善患者报告的生活质量有关，并有助于早日返回工作或学校。然而，密切监测基线生活质量较低的患者,以优化其整体OPAT体验至关重要.
