PDF(Pubmed)
Abstract：
UNASSIGNED: To review postoperative necrotizing enterocolitis (NEC) in patients with jejunoileal atresia (JIA) and to explore the potential risk factors related to the concurrence of NEC.
UNASSIGNED: Patients diagnosed with JIA who received surgical treatment from January 2016 to June 2021 were enrolled. Demographics, viral infection of the fetus, transfusion within 48 hours before NEC, sepsis before JIA repair, pathological and anatomical classification of JIA, combined malformation, occurrence time of NEC after the operation, treatment, and prognosis of patients were analyzed. Patients were divided into NEC group and non-NEC group, and all patients were followed up for 3-6 months to observe for complications.
UNASSIGNED: A total of 180 patients with JIA were included, of whom 12 were diagnosed with NEC after surgery and 1 patient with NEC died during follow-up. The average age, birth weight, gestational age, proportion of premature infants, proportion of preoperative infections, and pathological classification of JIA did not significantly differ between the two groups. The probability of patients with proximal jejunal atresia (PJA) in the NEC group (58.3%) was higher than that in the non-NEC group (22.6%) (p=0.011), and patients with PJA had longer parenteral nutrition time than patients without PJA (26.64±9.21 days vs 15.11±6.58 days, p<0.001).
UNASSIGNED: PJA was more likely to be associated with concurrent NEC after surgery, which is a highly NEC-related risk factor inherent in JIA.
UNASSIGNED: Patients diagnosed with JIA who received surgical treatment from January 2016 to June 2021 were enrolled. Demographics, viral infection of the fetus, transfusion within 48 hours before NEC, sepsis before JIA repair, pathological and anatomical classification of JIA, combined malformation, occurrence time of NEC after the operation, treatment, and prognosis of patients were analyzed. Patients were divided into NEC group and non-NEC group, and all patients were followed up for 3-6 months to observe for complications.
UNASSIGNED: A total of 180 patients with JIA were included, of whom 12 were diagnosed with NEC after surgery and 1 patient with NEC died during follow-up. The average age, birth weight, gestational age, proportion of premature infants, proportion of preoperative infections, and pathological classification of JIA did not significantly differ between the two groups. The probability of patients with proximal jejunal atresia (PJA) in the NEC group (58.3%) was higher than that in the non-NEC group (22.6%) (p=0.011), and patients with PJA had longer parenteral nutrition time than patients without PJA (26.64±9.21 days vs 15.11±6.58 days, p<0.001).
UNASSIGNED: PJA was more likely to be associated with concurrent NEC after surgery, which is a highly NEC-related risk factor inherent in JIA.
摘要：
■回顾空肠闭锁（JIA）患者术后坏死性小肠结肠炎（NEC），并探讨与NEC并发相关的潜在危险因素。
■纳入2016年1月至2021年6月接受手术治疗的JIA患者。人口统计,胎儿的病毒感染,在NEC前48小时内输血，JIA修复前的败血症,JIA的病理和解剖分类，合并畸形，手术后NEC发生时间,治疗,并对患者的预后进行分析。患者分为NEC组和非NEC组,所有患者均随访3～6个月,观察并发症发生情况。
■共包括180名JIA患者，其中12例手术后被诊断为NEC，1例NEC患者在随访期间死亡。平均年龄,出生体重,胎龄,早产儿的比例，术前感染比例，JIA的病理分类在两组之间没有显着差异。NEC组患者出现近端空肠闭锁(PJA)的概率(58.3%)高于非NEC组(22.6%)(p=0.011),PJA患者的肠外营养时间长于无PJA患者（26.64±9.21天比15.11±6.58天，p<0.001)。
■PJA更可能与手术后并发NEC有关，这是JIA固有的与NEC高度相关的风险因素。
■纳入2016年1月至2021年6月接受手术治疗的JIA患者。人口统计,胎儿的病毒感染,在NEC前48小时内输血，JIA修复前的败血症,JIA的病理和解剖分类，合并畸形，手术后NEC发生时间,治疗,并对患者的预后进行分析。患者分为NEC组和非NEC组,所有患者均随访3～6个月,观察并发症发生情况。
■共包括180名JIA患者，其中12例手术后被诊断为NEC，1例NEC患者在随访期间死亡。平均年龄,出生体重,胎龄,早产儿的比例，术前感染比例，JIA的病理分类在两组之间没有显着差异。NEC组患者出现近端空肠闭锁(PJA)的概率(58.3%)高于非NEC组(22.6%)(p=0.011),PJA患者的肠外营养时间长于无PJA患者（26.64±9.21天比15.11±6.58天，p<0.001)。
■PJA更可能与手术后并发NEC有关，这是JIA固有的与NEC高度相关的风险因素。
