PDF(Pubmed)
Abstract：
Background: Prevalence of type 2 diabetes (T2D) is rising, and its burden on the healthcare system remains a challenge. Consumption of a plant-predominant diet is a promising approach for achieving remission, which has emerged as a therapeutic target. Objective: To establish feasibility of achieving T2D remission with a plant-predominant diet in a cohort of free-living individuals. Methods: Patients referred to a wellness clinic were treated with a low-fat, whole food, plant-predominant diet while receiving standard medical treatment. Included patients were adults, mostly elderly, with HbA1c > 6.5%, with or without use of antidiabetic medications. Results: N = 59 patients were included in this analysis, with mean age 71.5 years (range 41-89). Twenty-two (37%) patients achieved T2D remission. Mean differences showed a significant decrease post-lifestyle change (T2) compared to prior to lifestyle change (T1) for the following outcomes [least squares mean difference (95% CI)]: BMI [-2.6 (-4.8, -.3)] kg/m2; HbA1c [ -1.3 (-1.6, -1.0)] %; and fasting glucose [-29.6 (-41.8, -17.5)] mg/dL. No significant differences were observed for systolic or diastolic blood pressure, HDL, LDL, or triglycerides. Conclusion: A lifestyle-based treatment intervention promoting adherence to a plant-predominant diet and integrated as part of routine care can successfully achieve T2D remission in wellness clinic patients.
摘要：
背景：2型糖尿病（T2D）的患病率正在上升，它对医疗保健系统的负担仍然是一个挑战。食用植物为主的饮食是实现缓解的一种有希望的方法，已经成为治疗靶点。目的：确定在自由生活的人群中以植物为主的饮食实现T2D缓解的可行性。方法：转诊到健康诊所的患者接受低脂治疗，整个食物,植物为主的饮食，同时接受标准的医疗。包括成人患者，大多是老年人，HbA1c>6.5%，使用或不使用抗糖尿病药物。结果：N=59例患者纳入本分析，平均年龄71.5岁（范围41-89）。22例（37%）患者获得T2D缓解。平均差异显示，生活方式改变后（T2）与生活方式改变前（T1）相比，以下结果[最小二乘平均差（95％CI）]显着降低：BMI[-2.6（-4.8，-0.3）]kg/m2;HbA1c[-1.3（-1.6，-1.0）]％;空腹血糖[-29.6（-41.8，-17.5）]mg/dL。收缩压或舒张压无明显差异，HDL,LDL,或甘油三酯。结论：基于生活方式的治疗干预可促进对植物主导饮食的依从性，并作为常规护理的一部分进行整合，可成功实现健康门诊患者的T2D缓解。
