PDF(Pubmed)
Abstract：
Rodents, particularly mice and rats, are extensively utilized in fundamental neuroscience research. Brain atlases have played a pivotal role in this field, evolving from traditional printed histology atlases to digital atlases incorporating diverse imaging datasets. Magnetic resonance imaging (MRI)-based brain atlases, also known as brain maps, have been employed in specific studies. However, the existence of numerous versions of MRI-based brain atlases has impeded their standardized application and widespread use, despite the consensus within the academic community regarding their significance in mice and rats. Furthermore, there is a dearth of comprehensive and systematic reviews on MRI-based brain atlases for rodents. This review aims to bridge this gap by providing a comprehensive overview of the advancements in MRI-based brain atlases for rodents, with a specific focus on mice and rats. It seeks to explore the advantages and disadvantages of histologically printed brain atlases in comparison to MRI brain atlases, delineate the standardized methods for creating MRI brain atlases, and summarize their primary applications in neuroscience research. Additionally, this review aims to assist researchers in selecting appropriate versions of MRI brain atlases for their studies or refining existing MRI brain atlas resources, thereby facilitating the development and widespread adoption of standardized MRI-based brain atlases in rodents.
摘要：
啮齿动物,特别是老鼠,广泛用于基础神经科学研究。大脑图谱在这一领域发挥了关键作用，从传统的印刷组织学地图集演变为包含不同成像数据集的数字地图集。磁共振成像（MRI）为基础的脑图谱，也被称为大脑图，已被用于具体研究。然而,基于MRI的大脑图谱的众多版本的存在阻碍了它们的标准化应用和广泛使用，尽管学术界就它们在小鼠和大鼠中的重要性达成了共识。此外，缺乏对基于MRI的啮齿动物脑图谱的全面和系统评价。这篇综述旨在通过全面概述基于MRI的啮齿动物脑图谱的进展来弥合这一差距。特别关注老鼠。它旨在探索组织学打印的脑图谱与MRI脑图谱相比的优缺点，描绘创建MRI脑图谱的标准化方法，并总结其在神经科学研究中的主要应用。此外,这篇综述旨在帮助研究人员为他们的研究选择合适的MRI脑图谱版本或完善现有的MRI脑图谱资源，从而促进了啮齿动物中基于MRI的标准化脑图谱的开发和广泛采用。
