PDF(Pubmed)
Abstract：
Regulatory T cells (Tregs) expressing the transcription factor FoxP3 are essential for maintaining immunological balance and are a significant component of the immunosuppressive tumor microenvironment (TME). Single-cell RNA sequencing (ScRNA-seq) technology has shown that Tregs exhibit significant plasticity and functional diversity in various tumors within the TME. This results in Tregs playing a dual role in the TME, which is not always centered around supporting tumor progression as typically believed. Abundant data confirms the anti-tumor activities of Tregs and their correlation with enhanced patient prognosis in specific types of malignancies. In this review, we summarize the potential anti-tumor actions of Tregs, including suppressing tumor-promoting inflammatory responses and boosting anti-tumor immunity. In addition, this study outlines the spatial and temporal variations in Tregs function to emphasize that their predictive significance in malignancies may change. It is essential to comprehend the functional diversity and potential anti-tumor effects of Tregs to improve tumor therapy strategies.
摘要：
表达转录因子FoxP3的调节性T细胞（Tregs）对于维持免疫平衡至关重要，并且是免疫抑制肿瘤微环境（TME）的重要组成部分。单细胞RNA测序（ScRNA-seq）技术表明，Treg在TME内的各种肿瘤中表现出明显的可塑性和功能多样性。这导致Tregs在TME中扮演双重角色，这并不总是像通常认为的那样围绕支持肿瘤进展。大量数据证实了Tregs的抗肿瘤活性及其与特定类型恶性肿瘤患者预后增强的相关性。在这次审查中,我们总结了Tregs的潜在抗肿瘤作用，包括抑制促进肿瘤的炎症反应和增强抗肿瘤免疫力。此外,本研究概述了Tregs功能的时空变化,以强调其在恶性肿瘤中的预测意义可能发生变化.了解Tregs的功能多样性和潜在的抗肿瘤作用对于改善肿瘤治疗策略至关重要。
