Abstract：
Solute carrier family 40 member 1 (SLC40A1) plays an essential role in transporting iron from intracellular to extracellular environments. When SLC40A1 expression is abnormal, cellular iron metabolism becomes dysregulated, resulting in an overload of intracellular iron, which induces cell ferroptosis. Numerous studies have confirmed that ferroptosis is closely associated with the development of many diseases. Here, we review recent findings on SLC40A1 in ferroptosis and its association with various diseases, intending to explore new directions for research on disease pathogenesis and new therapeutic targets for prevention and treatment. This article is categorized under: Cancer > Genetics/Genomics/Epigenetics Metabolic Diseases > Molecular and Cellular Physiology.
摘要：
溶质载体家族40成员1(SLC40A1)在将铁从细胞内环境运输到细胞外环境中起着至关重要的作用。当SLC40A1表达异常时，细胞铁代谢失调，导致细胞内铁过载，诱导细胞铁性凋亡。大量研究证实，铁性凋亡与许多疾病的发生发展密切相关。这里,我们回顾了SLC40A1在铁死亡中的最新发现及其与各种疾病的关系，旨在探索疾病发病机制研究的新方向和防治的新治疗靶点。本文分为：癌症>遗传学/基因组学/表观遗传学代谢疾病>分子和细胞生理学。
