PDF(Pubmed)
Abstract：
Preweaning mortality is a widespread problem in laboratory mouse breeding, particularly in the case of fragile mouse models. While numerous studies explore alternative care methods to increase the survivability of common mouse strains, there remains a paucity of research into the care of mice with fragile health conditions that result from induced or natural genetic mutations. In this study, standard husbandry practices were enhanced by the addition of a softened diet, a nutritionally fortified dietary supplement, soft bedding, gentle handling techniques, decreased handling, lengthened weaning age, and dam productivity tracking. This alternative care plan was shown to increase the survival of a fragile recessive dystrophic epidermolysis bullosa mouse model, and some aspects could be used in developing a care plan for other fragile mouse strains.
摘要：
断奶前死亡率是实验室小鼠育种中普遍存在的问题,特别是在脆弱的小鼠模型的情况下。虽然许多研究探索替代护理方法来增加普通小鼠品系的生存能力，对因诱发或自然遗传突变而导致健康状况脆弱的小鼠的护理研究仍然很少。在这项研究中,通过增加软化的饮食，标准的畜牧业做法得到了加强，一种营养强化的膳食补充剂，柔软的床上用品,温和的处理技术，减少处理，延长断奶年龄，和大坝生产力跟踪。这种替代护理计划被证明可以增加脆弱的隐性营养不良性大疱性表皮松解症小鼠模型的存活率。某些方面可用于制定其他脆弱小鼠品系的护理计划。
