Abstract：
BACKGROUND: Open reduction with internal fixation is the preferred treatment option for displaced facial bone fractures. The superior mechanical properties of metallic plates have made them the most widely used material in existing bone fixation systems. However, after the healing period, these permanent plates can cause various problems. Alternative bioresorbable materials are being investigated to reduce these potential problems. This study compares bone stability and viability by using graphene oxide (GO)-doped poly-lactic-co-glycolic acid (PLGA) nanofiber plates and titanium plates for rats with fractured mandibles.
METHODS: The study included 20 male Sprague-Dawley rats, divided into four groups: a control group (Group I), a mandibular fracture group with no additional application (Group II), a mandibular fracture group repaired with titanium plates (Group III), and a mandibular fracture group repaired with GO-PLGA plates (Group IV). After 2 months, all of the rats were euthanized. A bone compression test was performed to assess bone stability, and a histological examination was performed to evaluate bone healing.
RESULTS: The osteocyte lacunae, Haversian ducts, canaliculi, and vascular structures of Group IV were found to be higher. In the compression test, vertical compression was applied to the bone axis, and Group IV had a higher maximum load and maximum stretch. GO-PLGA plates were found to be statistically superior to titanium plates in terms of both bone stability and bone healing (p < 0.05).
CONCLUSIONS: The present study found that GO-PLGA plates are more effective than titanium plates for the treatment of mandibular corpus fractures.
METHODS: The study included 20 male Sprague-Dawley rats, divided into four groups: a control group (Group I), a mandibular fracture group with no additional application (Group II), a mandibular fracture group repaired with titanium plates (Group III), and a mandibular fracture group repaired with GO-PLGA plates (Group IV). After 2 months, all of the rats were euthanized. A bone compression test was performed to assess bone stability, and a histological examination was performed to evaluate bone healing.
RESULTS: The osteocyte lacunae, Haversian ducts, canaliculi, and vascular structures of Group IV were found to be higher. In the compression test, vertical compression was applied to the bone axis, and Group IV had a higher maximum load and maximum stretch. GO-PLGA plates were found to be statistically superior to titanium plates in terms of both bone stability and bone healing (p < 0.05).
CONCLUSIONS: The present study found that GO-PLGA plates are more effective than titanium plates for the treatment of mandibular corpus fractures.
摘要：
背景：切开复位内固定是移位面骨骨折的首选治疗选择。金属板的优异机械性能使其成为现有骨固定系统中使用最广泛的材料。然而,在愈合期之后,这些永久板可能会导致各种问题。正在研究替代的生物可吸收材料以减少这些潜在的问题。这项研究通过使用氧化石墨烯（GO）掺杂的聚乳酸共乙醇酸（PLGA）纳米纤维板和钛板对下颌骨骨折大鼠的骨稳定性和活力进行了比较。
方法：本研究包括20只雄性Sprague-Dawley大鼠，分为四组：对照组（I组），下颌骨骨折组，没有额外的应用（组II），用钛板修复的下颌骨骨折组（组III），下颌骨骨折组用GO-PLGA钢板修复（组IV）。两个月后,所有的大鼠都被安乐死。进行骨压缩试验以评估骨稳定性，并进行组织学检查以评估骨愈合。
结果：骨细胞腔隙，Haversian管道,Canalculi,发现IV组的血管结构更高。在压缩测试中，对骨骼轴施加垂直压缩，第IV组有较高的最大负荷和最大拉伸。发现GO-PLGA板在骨稳定性和骨愈合方面在统计学上优于钛板(p<0.05)。
结论：本研究发现GO-PLGA钢板比钛钢板治疗下颌骨体骨折更有效。
方法：本研究包括20只雄性Sprague-Dawley大鼠，分为四组：对照组（I组），下颌骨骨折组，没有额外的应用（组II），用钛板修复的下颌骨骨折组（组III），下颌骨骨折组用GO-PLGA钢板修复（组IV）。两个月后,所有的大鼠都被安乐死。进行骨压缩试验以评估骨稳定性，并进行组织学检查以评估骨愈合。
结果：骨细胞腔隙，Haversian管道,Canalculi,发现IV组的血管结构更高。在压缩测试中，对骨骼轴施加垂直压缩，第IV组有较高的最大负荷和最大拉伸。发现GO-PLGA板在骨稳定性和骨愈合方面在统计学上优于钛板(p<0.05)。
结论：本研究发现GO-PLGA钢板比钛钢板治疗下颌骨体骨折更有效。
