PDF(Pubmed)
Abstract：
UNASSIGNED: Some evidence suggests that cannabidiol (CBD) has potential to help alleviate HIV symptoms due to its antioxidant and anti-inflammatory properties. Here we examined acute CBD effects on various behaviors and the endocannabinoid system in HIV Tat transgenic mice.
UNASSIGNED: Tat transgenic mice (female/male) were injected with CBD (3, 10, 30 mg/kg) and assessed for antinociception, activity, coordination, anxiety-like behavior, and recognition memory. Brains were taken to quantify endocannabinoids, cannabinoid receptors, and cannabinoid catabolic enzymes. Additionally, CBD and metabolite 7-hydroxy-CBD were quantified in the plasma and cortex.
UNASSIGNED: Tat decreased supraspinal-related nociception and locomotion. CBD and sex had little to no effects on any of the behavioral measures. For the endocannabinoid system male sex was associated with elevated concentration of the proinflammatory metabolite arachidonic acid in various CNS regions, including the cerebellum that also showed higher FAAH expression levels for Tat(+) males. GPR55 expression levels in the striatum and cerebellum were higher for females compared to males. CBD metabolism was altered by sex and Tat expression.
UNASSIGNED: Findings indicate that acute CBD effects are not altered by HIV Tat, and acute CBD has no to minimal effects on behavior and the endocannabinoid system.
UNASSIGNED: Tat transgenic mice (female/male) were injected with CBD (3, 10, 30 mg/kg) and assessed for antinociception, activity, coordination, anxiety-like behavior, and recognition memory. Brains were taken to quantify endocannabinoids, cannabinoid receptors, and cannabinoid catabolic enzymes. Additionally, CBD and metabolite 7-hydroxy-CBD were quantified in the plasma and cortex.
UNASSIGNED: Tat decreased supraspinal-related nociception and locomotion. CBD and sex had little to no effects on any of the behavioral measures. For the endocannabinoid system male sex was associated with elevated concentration of the proinflammatory metabolite arachidonic acid in various CNS regions, including the cerebellum that also showed higher FAAH expression levels for Tat(+) males. GPR55 expression levels in the striatum and cerebellum were higher for females compared to males. CBD metabolism was altered by sex and Tat expression.
UNASSIGNED: Findings indicate that acute CBD effects are not altered by HIV Tat, and acute CBD has no to minimal effects on behavior and the endocannabinoid system.
摘要：
■一些证据表明，大麻二酚（CBD）由于其抗氧化和抗炎特性，有可能帮助缓解HIV症状。在这里，我们研究了CBD对HIVTat转基因小鼠各种行为和内源性大麻素系统的急性影响。
■Tat转基因小鼠（雌性/雄性）注射CBD（3、10、30mg/kg）并评估其抗伤害作用，活动,协调,类似焦虑的行为，和识别记忆。大脑被用来量化内源性大麻素，大麻素受体,和大麻素分解代谢酶。此外,在血浆和皮质中定量CBD和代谢物7-羟基-CBD。
■Tat降低了脊柱上相关的伤害性感受和运动。CBD和性别对任何行为措施几乎没有影响。对于内源性大麻素系统，男性与各个CNS区域的促炎代谢物花生四烯酸浓度升高有关，包括Tat（）男性的小脑也显示出更高的FAAH表达水平。女性的纹状体和小脑中的GPR55表达水平高于男性。CBD代谢因性别和Tat表达而改变。
■研究结果表明，HIVTat不会改变急性CBD效应，和急性CBD对行为和内源性大麻素系统没有最小的影响。
■Tat转基因小鼠（雌性/雄性）注射CBD（3、10、30mg/kg）并评估其抗伤害作用，活动,协调,类似焦虑的行为，和识别记忆。大脑被用来量化内源性大麻素，大麻素受体,和大麻素分解代谢酶。此外,在血浆和皮质中定量CBD和代谢物7-羟基-CBD。
■Tat降低了脊柱上相关的伤害性感受和运动。CBD和性别对任何行为措施几乎没有影响。对于内源性大麻素系统，男性与各个CNS区域的促炎代谢物花生四烯酸浓度升高有关，包括Tat（）男性的小脑也显示出更高的FAAH表达水平。女性的纹状体和小脑中的GPR55表达水平高于男性。CBD代谢因性别和Tat表达而改变。
■研究结果表明，HIVTat不会改变急性CBD效应，和急性CBD对行为和内源性大麻素系统没有最小的影响。
