PDF(Pubmed)
Abstract：
UNASSIGNED: Endocavity ultrasound (US) imaging is a frequently employed diagnostic technique in gynecology and urology for the assessment of male and female genital diseases that present challenges for conventional transabdominal imaging. The integration of photoacoustic (PA) imaging with clinical US imaging has displayed promising outcomes in clinical research. Nonetheless, its application has been constrained due to size limitations, restricting it to spatially confined locations such as vaginal or rectal canals.
UNASSIGNED: This study presents the development of a video-rate (20 Hz) endocavity PA/harmonic US imaging (EPAUSI) system.
UNASSIGNED: The approach incorporates a commercially available endocavity US probe with a miniaturized laser delivery unit, comprised of a single large-core fiber and a line beamshaping engineered diffuser. The system facilitates real-time image display and subsequent processing, including angular energy density correction and spectral unmixing, in offline mode.
UNASSIGNED: The spatial resolutions of the concurrently acquired PA and harmonic US images were measured at 318 μm and 291 μm in the radial direction, respectively, and 1.22 deg and 1.50 deg in the angular direction, respectively. Furthermore, the system demonstrated its capability in multispectral PA imaging by successfully distinguishing two clinical dyes in a tissue-mimicking phantom. Its rapid temporal resolution enabled the capture of kinetic dye perfusion into an ex vivo porcine ovary through the depth of porcine uterine tissue. EPAUSI proved its clinical viability by detecting pulsating hemodynamics in the male rat\'s prostate in vivo and accurately classifying human blood vessels into arteries and veins based on sO2 measurements.
UNASSIGNED: Our proposed EPAUSI system holds the potential to unveil previously overlooked indicators of vascular alterations in genital cancers or endometriosis, addressing pressing requirements in the fields of gynecology and urology.
UNASSIGNED: This study presents the development of a video-rate (20 Hz) endocavity PA/harmonic US imaging (EPAUSI) system.
UNASSIGNED: The approach incorporates a commercially available endocavity US probe with a miniaturized laser delivery unit, comprised of a single large-core fiber and a line beamshaping engineered diffuser. The system facilitates real-time image display and subsequent processing, including angular energy density correction and spectral unmixing, in offline mode.
UNASSIGNED: The spatial resolutions of the concurrently acquired PA and harmonic US images were measured at 318 μm and 291 μm in the radial direction, respectively, and 1.22 deg and 1.50 deg in the angular direction, respectively. Furthermore, the system demonstrated its capability in multispectral PA imaging by successfully distinguishing two clinical dyes in a tissue-mimicking phantom. Its rapid temporal resolution enabled the capture of kinetic dye perfusion into an ex vivo porcine ovary through the depth of porcine uterine tissue. EPAUSI proved its clinical viability by detecting pulsating hemodynamics in the male rat\'s prostate in vivo and accurately classifying human blood vessels into arteries and veins based on sO2 measurements.
UNASSIGNED: Our proposed EPAUSI system holds the potential to unveil previously overlooked indicators of vascular alterations in genital cancers or endometriosis, addressing pressing requirements in the fields of gynecology and urology.
摘要：
■腔内超声（US）成像是妇科和泌尿科中常用的诊断技术，用于评估男性和女性生殖器疾病，这对传统的经腹成像提出了挑战。光声（PA）成像与临床US成像的整合在临床研究中显示出了有希望的结果。尽管如此，由于尺寸限制，其应用受到限制，将其限制在空间狭窄的位置，例如阴道或直肠管。
■本研究提出了视频速率（20Hz）内腔PA/谐波US成像（EPAUSI）系统的开发。
■该方法结合了市售的带有小型化激光传输单元的内腔US探头，由一个大芯光纤和一个线光束成形工程扩散器。该系统便于实时图像显示和后续处理，包括角能量密度校正和光谱解混，在脱机模式下。
■同时获取的PA和谐波US图像的空间分辨率在径向方向上在318μm和291μm处测量，分别,角度方向为1.22度和1.50度，分别。此外，该系统通过成功区分组织模拟体模中的两种临床染料，证明了其在多光谱PA成像中的能力。其快速的时间分辨率能够通过猪子宫组织的深度将动力学染料灌注捕获到离体猪卵巢中。EPAUSI通过在体内检测雄性大鼠前列腺中的脉动血液动力学并根据sO2测量将人血管准确分类为动脉和静脉来证明其临床可行性。
■我们提出的EPAUSI系统有可能揭示以前被忽视的生殖器癌症或子宫内膜异位症血管改变的指标，解决妇科和泌尿外科领域的紧迫要求。
■本研究提出了视频速率（20Hz）内腔PA/谐波US成像（EPAUSI）系统的开发。
■该方法结合了市售的带有小型化激光传输单元的内腔US探头，由一个大芯光纤和一个线光束成形工程扩散器。该系统便于实时图像显示和后续处理，包括角能量密度校正和光谱解混，在脱机模式下。
■同时获取的PA和谐波US图像的空间分辨率在径向方向上在318μm和291μm处测量，分别,角度方向为1.22度和1.50度，分别。此外，该系统通过成功区分组织模拟体模中的两种临床染料，证明了其在多光谱PA成像中的能力。其快速的时间分辨率能够通过猪子宫组织的深度将动力学染料灌注捕获到离体猪卵巢中。EPAUSI通过在体内检测雄性大鼠前列腺中的脉动血液动力学并根据sO2测量将人血管准确分类为动脉和静脉来证明其临床可行性。
■我们提出的EPAUSI系统有可能揭示以前被忽视的生殖器癌症或子宫内膜异位症血管改变的指标，解决妇科和泌尿外科领域的紧迫要求。
