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Abstract：
OBJECTIVE: Oral squamous cell carcinoma (OSCC) is one of the most common malignancies in the head and neck region. Particularly, high incidence rates are observed in South and Southeast Asia, attributed to the widespread use of the carcinogenic areca nut. This study aimed to investigate the clinical, epidemiological, and histopathological features of OSCC, identify prognostic factors impacting disease-free survival, and determine a post-diagnosis disease-free survival time of OSCC patients.
METHODS: Employing a descriptive cross-sectional design, the study conducted a thorough examination of the clinical, epidemiological, and histopathological aspects of OSCC among patients seeking care at a tertiary healthcare facility. Participants were personally interviewed if available, while information for unreachable or deceased individuals was extracted from archival patient records in the Oral and Maxillofacial Surgery Department, Bakhtawar Amin Medical and Dental College, Multan, Pakistan. Data analysis was performed with a significance level set at p ≤ 0.05.
RESULTS: The mean age of the patients was 54.16 ± 11.1, with a notable concentration in the 41 years and above age group, indicating a significant prevalence of OSCC in this population. The data revealed a gender bias toward males, and a substantial proportion of patients, particularly those aged 41 years and above, had unfortunately passed away. Statistical analysis using the Fisher exact test showed a significant association between age groups and patients\' current living status (p-value < 0.05).
CONCLUSIONS: Histopathologically, moderately differentiated OSCC was the most frequently encountered grade, and surgery emerged as the predominant treatment modality. The majority of patients studied had a survival period of three years or less, emphasizing the need for further exploration of factors influencing prognosis and treatment outcomes in OSCC.
METHODS: Employing a descriptive cross-sectional design, the study conducted a thorough examination of the clinical, epidemiological, and histopathological aspects of OSCC among patients seeking care at a tertiary healthcare facility. Participants were personally interviewed if available, while information for unreachable or deceased individuals was extracted from archival patient records in the Oral and Maxillofacial Surgery Department, Bakhtawar Amin Medical and Dental College, Multan, Pakistan. Data analysis was performed with a significance level set at p ≤ 0.05.
RESULTS: The mean age of the patients was 54.16 ± 11.1, with a notable concentration in the 41 years and above age group, indicating a significant prevalence of OSCC in this population. The data revealed a gender bias toward males, and a substantial proportion of patients, particularly those aged 41 years and above, had unfortunately passed away. Statistical analysis using the Fisher exact test showed a significant association between age groups and patients\' current living status (p-value < 0.05).
CONCLUSIONS: Histopathologically, moderately differentiated OSCC was the most frequently encountered grade, and surgery emerged as the predominant treatment modality. The majority of patients studied had a survival period of three years or less, emphasizing the need for further exploration of factors influencing prognosis and treatment outcomes in OSCC.
摘要：
目的：口腔鳞状细胞癌（OSCC）是头颈部最常见的恶性肿瘤之一。特别是,在南亚和东南亚观察到高发病率，归因于致癌槟榔的广泛使用。本研究旨在探讨临床,流行病学,和OSCC的组织病理学特征，确定影响无病生存的预后因素，并确定OSCC患者的诊断后无病生存时间。
方法：采用描述性横截面设计，这项研究对临床进行了彻底的检查，流行病学,在三级医疗机构寻求治疗的患者中OSCC的组织病理学方面。参与者亲自面试，如果有的话，虽然无法联系或死亡的人的信息是从口腔颌面外科的存档患者记录中提取的，BakhtawarAmin医学和牙科学院，木尔坦,巴基斯坦。在p≤0.05的显著性水平下进行数据分析。
结果：患者平均年龄为54.16±11.1，41岁及以上年龄组明显集中，表明OSCC在该人群中的显著患病率。数据揭示了对男性的性别偏见，相当比例的病人，特别是41岁及以上的人，不幸去世了。使用Fisher精确检验的统计学分析显示年龄组与患者当前生存状态之间存在显著关联(p值<0.05)。
结论：组织病理学，中度分化OSCC是最常遇到的级别，手术成为主要的治疗方式。研究的大多数患者的生存期为三年或更短，强调需要进一步探索影响OSCC预后和治疗结果的因素。
方法：采用描述性横截面设计，这项研究对临床进行了彻底的检查，流行病学,在三级医疗机构寻求治疗的患者中OSCC的组织病理学方面。参与者亲自面试，如果有的话，虽然无法联系或死亡的人的信息是从口腔颌面外科的存档患者记录中提取的，BakhtawarAmin医学和牙科学院，木尔坦,巴基斯坦。在p≤0.05的显著性水平下进行数据分析。
结果：患者平均年龄为54.16±11.1，41岁及以上年龄组明显集中，表明OSCC在该人群中的显著患病率。数据揭示了对男性的性别偏见，相当比例的病人，特别是41岁及以上的人，不幸去世了。使用Fisher精确检验的统计学分析显示年龄组与患者当前生存状态之间存在显著关联(p值<0.05)。
结论：组织病理学，中度分化OSCC是最常遇到的级别，手术成为主要的治疗方式。研究的大多数患者的生存期为三年或更短，强调需要进一步探索影响OSCC预后和治疗结果的因素。
