PDF(Pubmed)
Abstract：
UNASSIGNED: Pulmonary tuberculosis (PTB) is a major public health concern in most underdeveloped and developing countries. PTB affects the nutritional status of the patients and influences the body mass index (BMI). There is tissue inflammation and free radical burst from activated phagocytes resulting in oxidative stress. The present study was designed to assess the relationship between oxidative stress and body mass index in newly detected pulmonary tuberculosis patients.
UNASSIGNED: This was a case-control study designed to assess oxidative stress parameters such as nitric oxide (NO) and malondialdehyde (MDA) in 40 consecutives newly diagnosed PTB patients and compared with 40 age-matched healthy controls. The nutritional status of the study subjects was measured by calculating the BMI.
UNASSIGNED: The mean BMI was 21.61±3.52 Kg/m2 in controls and 17.47±1.56 Kg/m2 in PTB patients and the difference was statistically significant (p <0.0001). The mean levels of MDA (7.65±0.65 nmol/ml) and NO (36.12±1.07 μmol/l) were significantly higher in PTB patients compared to controls (MDA 3.56±0.41 nmol/ml and NO 14.48±0.93 μmol/l).
UNASSIGNED: Increased levels of malondialdehyde and nitric oxide were observed in newly diagnosed PTB patients when compared to controls indicating oxidative stress in PTB. The BMI of these patients was significantly lower than the controls. Thus, it is concluded that there is an inverse relationship between oxidative stress and BMI in PTB patients and antioxidant supplementation in addition to nutritional intervention under the National Tuberculosis Elimination Program may help to improve the BMI and promote better recovery in these patients.
UNASSIGNED: This was a case-control study designed to assess oxidative stress parameters such as nitric oxide (NO) and malondialdehyde (MDA) in 40 consecutives newly diagnosed PTB patients and compared with 40 age-matched healthy controls. The nutritional status of the study subjects was measured by calculating the BMI.
UNASSIGNED: The mean BMI was 21.61±3.52 Kg/m2 in controls and 17.47±1.56 Kg/m2 in PTB patients and the difference was statistically significant (p <0.0001). The mean levels of MDA (7.65±0.65 nmol/ml) and NO (36.12±1.07 μmol/l) were significantly higher in PTB patients compared to controls (MDA 3.56±0.41 nmol/ml and NO 14.48±0.93 μmol/l).
UNASSIGNED: Increased levels of malondialdehyde and nitric oxide were observed in newly diagnosed PTB patients when compared to controls indicating oxidative stress in PTB. The BMI of these patients was significantly lower than the controls. Thus, it is concluded that there is an inverse relationship between oxidative stress and BMI in PTB patients and antioxidant supplementation in addition to nutritional intervention under the National Tuberculosis Elimination Program may help to improve the BMI and promote better recovery in these patients.
摘要：
肺结核（PTB）是大多数不发达国家和发展中国家的主要公共卫生问题。PTB影响患者的营养状况并影响体重指数（BMI）。存在组织炎症和自由基从活化的吞噬细胞爆发,导致氧化应激。本研究旨在评估新发现的肺结核患者中氧化应激与体重指数之间的关系。
这是一项病例对照研究，旨在评估40例连续新诊断的PTB患者的氧化应激参数，例如一氧化氮（NO）和丙二醛（MDA），并与40例年龄匹配的健康对照进行比较。通过计算BMI来测量研究对象的营养状况。
■对照组的平均BMI为21.61±3.52Kg/m2，PTB患者的平均BMI为17.47±1.56Kg/m2，差异有统计学意义（p<0.0001）。PTB患者的MDA（7.65±0.65nmol/ml）和NO（36.12±1.07μmol/l）的平均水平明显高于对照组（MDA3.56±0.41nmol/ml和NO14.48±0.93μmol/l）。
■与对照组相比，在新诊断的PTB患者中观察到丙二醛和一氧化氮水平升高，表明PTB中存在氧化应激。这些患者的BMI明显低于对照组。因此，结论是PTB患者的氧化应激与BMI之间存在负相关关系，在国家结核病消除计划下，除了营养干预外，补充抗氧化剂可能有助于改善BMI并促进这些患者的更好恢复。
这是一项病例对照研究，旨在评估40例连续新诊断的PTB患者的氧化应激参数，例如一氧化氮（NO）和丙二醛（MDA），并与40例年龄匹配的健康对照进行比较。通过计算BMI来测量研究对象的营养状况。
■对照组的平均BMI为21.61±3.52Kg/m2，PTB患者的平均BMI为17.47±1.56Kg/m2，差异有统计学意义（p<0.0001）。PTB患者的MDA（7.65±0.65nmol/ml）和NO（36.12±1.07μmol/l）的平均水平明显高于对照组（MDA3.56±0.41nmol/ml和NO14.48±0.93μmol/l）。
■与对照组相比，在新诊断的PTB患者中观察到丙二醛和一氧化氮水平升高，表明PTB中存在氧化应激。这些患者的BMI明显低于对照组。因此，结论是PTB患者的氧化应激与BMI之间存在负相关关系，在国家结核病消除计划下，除了营养干预外，补充抗氧化剂可能有助于改善BMI并促进这些患者的更好恢复。
