PDF(Pubmed)
Abstract：
UNASSIGNED: The opioid crisis has become a present concern in the medical field. In an effort to address these complications, antineuropathic pain medications have been considered as alternatives to prescribed opioids.
UNASSIGNED: This review focuses on the analgesic effects of neuromodulators, such as gabapentin, duloxetine, and pregabalin, that provide room for less dependence on narcotic analgesics following orthopedic surgery.
UNASSIGNED: During the database searches, 1,033 records were identified as a preliminary result. After duplicates were removed, an initial screen of each article was completed which identified records to be removed due to absence of a full-text article. Articles were excluded if they were not either prospective or retrospective, showcased an irrelevant medication (such as tricyclic antidepressants) which are not pertinent to this review, or deemed to be unrelated to the topic.
UNASSIGNED: Ultimately, 19 articles were selected. Three different drugs, gabapentin, pregabalin, and duloxetine, were analyzed to compile data on the effectiveness of preventing opioid overuse and addiction following hand surgery. This review identifies potential evidence that peri-operative gabapentin, pregabalin, and duloxetine administration decreases post-operative pain and lowers opioid dependency.
UNASSIGNED: Gabapentin, pregabalin, and duloxetine have potential to further decrease post-operative pain and lower opioid dependency. This review creates an opening for further research in hand surgery to assess an updated protocol for pain management to reduce opioid dependency.
UNASSIGNED: This review focuses on the analgesic effects of neuromodulators, such as gabapentin, duloxetine, and pregabalin, that provide room for less dependence on narcotic analgesics following orthopedic surgery.
UNASSIGNED: During the database searches, 1,033 records were identified as a preliminary result. After duplicates were removed, an initial screen of each article was completed which identified records to be removed due to absence of a full-text article. Articles were excluded if they were not either prospective or retrospective, showcased an irrelevant medication (such as tricyclic antidepressants) which are not pertinent to this review, or deemed to be unrelated to the topic.
UNASSIGNED: Ultimately, 19 articles were selected. Three different drugs, gabapentin, pregabalin, and duloxetine, were analyzed to compile data on the effectiveness of preventing opioid overuse and addiction following hand surgery. This review identifies potential evidence that peri-operative gabapentin, pregabalin, and duloxetine administration decreases post-operative pain and lowers opioid dependency.
UNASSIGNED: Gabapentin, pregabalin, and duloxetine have potential to further decrease post-operative pain and lower opioid dependency. This review creates an opening for further research in hand surgery to assess an updated protocol for pain management to reduce opioid dependency.
摘要：
■阿片类药物危机已成为医学领域当前关注的问题。为了解决这些并发症，抗神经性疼痛药物已被认为是处方阿片类药物的替代品。
■这篇综述集中在神经调质的镇痛作用，比如加巴喷丁,度洛西汀,还有普瑞巴林,这为骨科手术后对麻醉性镇痛药的依赖提供了空间。
■在数据库搜索期间，初步结果确定了1,033条记录。删除重复项后，完成了每篇文章的初始筛选，确定了由于没有全文文章而要删除的记录。如果文章不是前瞻性或回顾性的，则被排除在外，展示了与本综述无关的药物（如三环抗抑郁药），或被认为与主题无关。
■最终，选择了19篇文章。三种不同的药物,加巴喷丁,普瑞巴林,还有度洛西汀,进行了分析，以汇编有关预防手部手术后阿片类药物过度使用和成瘾的有效性的数据。这篇综述确定了围手术期加巴喷丁的潜在证据，普瑞巴林,度洛西汀可减少术后疼痛并降低阿片类药物依赖。
■加巴喷丁，普瑞巴林,度洛西汀有可能进一步减轻术后疼痛和降低阿片类药物依赖。这篇综述为手外科的进一步研究创造了一个机会，以评估疼痛管理以减少阿片类药物依赖的更新方案。
■这篇综述集中在神经调质的镇痛作用，比如加巴喷丁,度洛西汀,还有普瑞巴林,这为骨科手术后对麻醉性镇痛药的依赖提供了空间。
■在数据库搜索期间，初步结果确定了1,033条记录。删除重复项后，完成了每篇文章的初始筛选，确定了由于没有全文文章而要删除的记录。如果文章不是前瞻性或回顾性的，则被排除在外，展示了与本综述无关的药物（如三环抗抑郁药），或被认为与主题无关。
■最终，选择了19篇文章。三种不同的药物,加巴喷丁,普瑞巴林,还有度洛西汀,进行了分析，以汇编有关预防手部手术后阿片类药物过度使用和成瘾的有效性的数据。这篇综述确定了围手术期加巴喷丁的潜在证据，普瑞巴林,度洛西汀可减少术后疼痛并降低阿片类药物依赖。
■加巴喷丁，普瑞巴林,度洛西汀有可能进一步减轻术后疼痛和降低阿片类药物依赖。这篇综述为手外科的进一步研究创造了一个机会，以评估疼痛管理以减少阿片类药物依赖的更新方案。
