PDF(Pubmed)
Abstract：
Although pulmonary artery (PA) dilation is independently associated with significant morbidity and mortality in patients with pulmonary diseases irrespective of diagnosed pulmonary hypertension, its relationship with nontuberculous mycobacteria (NTM) is unknown. The Bronchiectasis and NTM Research Registry is a multicenter registry created to foster research in non-cystic fibrosis (CF) bronchiectasis and NTM lung disease. The majority of patients with non-CF bronchiectasis at Oregon Health & Science University have NTM infections. To determine the prevalence of PA dilation in these patients and its association with supplemental oxygen use, severity of bronchiectasis, tobacco use, and NTM in the sputum culture, we evaluated the chest computed tomography (CT) scans from 321 patients in a cross-sectional analysis. We measured the severity of bronchiectasis by applying modified Reiff criteria and measured the diameters of the PA and aorta (Ao), with PA dilation defined as a PA:Ao ratio >0.9. In our cohort, the mean age was 67.3 years and 83.2% were female. The mean modified Reiff score was 7.1, indicating moderate disease severity. Forty-two patients (13.1%) were found to have PA dilation. PA dilation was positively associated with the use of supplemental oxygen (P<0.001), but there was no association between PA dilation and NTM infection.
摘要：
尽管肺动脉（PA）扩张与肺部疾病患者的显着发病率和死亡率独立相关，而与诊断的肺动脉高压无关。其与非结核分枝杆菌（NTM）的关系尚不清楚。支气管扩张和NTM研究注册是一个多中心注册，旨在促进非囊性纤维化（CF）支气管扩张和NTM肺病的研究。俄勒冈健康与科学大学的大多数非CF支气管扩张患者患有NTM感染。为了确定这些患者中PA扩张的患病率及其与补充氧气使用的关联，支气管扩张的严重程度，烟草使用,和NTM在痰培养中，我们在横断面分析中评估了321例患者的胸部计算机断层扫描(CT).我们通过应用改良的Reiff标准来测量支气管扩张的严重程度，并测量PA和主动脉（Ao）的直径，其中PA扩张定义为PA:Ao比率>0.9。在我们的队列中，平均年龄为67.3岁,83.2%为女性.平均改良Reiff评分为7.1,表明中度疾病严重程度。42例患者（13.1％）被发现有PA扩张。PA扩张与补充氧气的使用呈正相关（P<0.001），但是PA扩张和NTM感染之间没有关联。
