PDF(Pubmed)
Abstract：
UNASSIGNED: Xanthelasma palpebrarum (XP) is the most common type of cutaneous xanthoma, characterized by yellowish cutaneous plaques commonly located near the medial canthus of the eyelid. Although dyslipidemia significantly contributes to its development, inflammation is also believed to be another element in the pathogenesis, especially in normolipidemic patients. Recently, cell counts derived from complete blood counts have been identified as indicators of systemic inflammatory conditions and have also been under discussion concerning their relevance to ocular diseases. This study aimed to assess inflammation indices derived from complete blood cell counts (CBC) in XP patients with normal lipid levels.
UNASSIGNED: Patients who had been referred to the oculoplasty department with the diagnosis of XP between January 2020 and January 2023 and age-matched control subjects were retrospectively reviewed. Patients who had abnormal lipid profiles and systemic diseases such as diabetes mellitus, hypertension, malignancy, cardiovascular diseases, systemic infections, and inflammatory diseases were not included in the study. CBC parameters were analyzed and compared between the groups.
UNASSIGNED: The study comprised 27 normolipidemic patients with XP and 27 age-matched healthy individuals as the control group. There were no statistically significant differences between the two groups in terms of age (p=0.143). The mean hemoglobin, neutrophil, monocyte, lymphocyte, platelet, neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, systemic immune-inflammation index, and aggregate index of systemic inflammation values were higher in the patient group, but the differences were not statistically significant (p>0.05). The mean red cell distribution width and platelet-to-lymphocyte ratio appeared to be lower in the patient group compared to the control group; however, no significant differences were observed between the two groups (p=0.272, p=0.387, respectively).
UNASSIGNED: This study might offer insights into the pathogenesis of XP, yet numerous questions remain unanswered, awaiting further investigation in future studies.
UNASSIGNED: Patients who had been referred to the oculoplasty department with the diagnosis of XP between January 2020 and January 2023 and age-matched control subjects were retrospectively reviewed. Patients who had abnormal lipid profiles and systemic diseases such as diabetes mellitus, hypertension, malignancy, cardiovascular diseases, systemic infections, and inflammatory diseases were not included in the study. CBC parameters were analyzed and compared between the groups.
UNASSIGNED: The study comprised 27 normolipidemic patients with XP and 27 age-matched healthy individuals as the control group. There were no statistically significant differences between the two groups in terms of age (p=0.143). The mean hemoglobin, neutrophil, monocyte, lymphocyte, platelet, neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, systemic immune-inflammation index, and aggregate index of systemic inflammation values were higher in the patient group, but the differences were not statistically significant (p>0.05). The mean red cell distribution width and platelet-to-lymphocyte ratio appeared to be lower in the patient group compared to the control group; however, no significant differences were observed between the two groups (p=0.272, p=0.387, respectively).
UNASSIGNED: This study might offer insights into the pathogenesis of XP, yet numerous questions remain unanswered, awaiting further investigation in future studies.
摘要：
■棕榈黄膜（XP）是最常见的皮肤黄色瘤，通常位于眼睑内侧can附近的黄色皮肤斑块。尽管血脂异常显著地促进了它的发展,炎症也被认为是发病机理的另一个因素，尤其是在血脂正常的患者中。最近,来自全血细胞计数的细胞计数已被确定为全身性炎症状况的指标,并且还在讨论它们与眼部疾病的相关性。这项研究旨在评估血脂水平正常的XP患者的全血细胞计数（CBC）得出的炎症指标。
■对在2020年1月至2023年1月期间转诊到眼成形术科诊断为XP的患者和年龄匹配的对照受试者进行回顾性分析。患者血脂异常和全身性疾病如糖尿病，高血压,恶性肿瘤，心血管疾病,全身性感染,和炎症性疾病不包括在研究中。对各组CBC参数进行分析比较。
■该研究包括27名XP患者和27名年龄匹配的健康个体作为对照组。两组患者年龄差异无统计学意义(p=0.143)。平均血红蛋白，中性粒细胞,单核细胞,淋巴细胞，血小板,中性粒细胞与淋巴细胞的比率，单核细胞与淋巴细胞的比率，全身免疫炎症指数，患者组的全身炎症综合指数较高，但差异无统计学意义(p>0.05)。与对照组相比，患者组的平均红细胞分布宽度和血小板与淋巴细胞之比似乎更低；然而，两组间无显著差异(分别为p=0.272,p=0.387).
■这项研究可能为XP的发病机理提供了见解，然而，许多问题仍然没有答案，在未来的研究中等待进一步的调查。
■对在2020年1月至2023年1月期间转诊到眼成形术科诊断为XP的患者和年龄匹配的对照受试者进行回顾性分析。患者血脂异常和全身性疾病如糖尿病，高血压,恶性肿瘤，心血管疾病,全身性感染,和炎症性疾病不包括在研究中。对各组CBC参数进行分析比较。
■该研究包括27名XP患者和27名年龄匹配的健康个体作为对照组。两组患者年龄差异无统计学意义(p=0.143)。平均血红蛋白，中性粒细胞,单核细胞,淋巴细胞，血小板,中性粒细胞与淋巴细胞的比率，单核细胞与淋巴细胞的比率，全身免疫炎症指数，患者组的全身炎症综合指数较高，但差异无统计学意义(p>0.05)。与对照组相比，患者组的平均红细胞分布宽度和血小板与淋巴细胞之比似乎更低；然而，两组间无显著差异(分别为p=0.272,p=0.387).
■这项研究可能为XP的发病机理提供了见解，然而，许多问题仍然没有答案，在未来的研究中等待进一步的调查。
