在年龄相关性视网膜变性的 CDHR1 模型中挽救视锥细胞和视杆细胞功能。
关键词: CDHR1 cadherin-related family member 1 cone-rod dystrophy gene supplementation gene therapy macular degeneration macular dystrophy optical coherence tomography protocadherin retinitis pigmentosa
Mesh : Animals Mice Disease Models, Animal Retinal Rod Photoreceptor Cells / metabolism pathology Cadherin Related Proteins Retinal Cone Photoreceptor Cells / metabolism pathology Cadherins / genetics metabolism Retinal Degeneration / genetics therapy etiology Humans Genetic Therapy / methods Macular Degeneration / therapy genetics pathology etiology metabolism Nerve Tissue Proteins
来 源:
DOI:10.1016/j.ymthe.2024.03.026
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