PDF(Pubmed)
Abstract：
BACKGROUND: The effects of organochlorine pesticide (OCP) exposure on the development of human papillary thyroid cancer (PTC) are not well understood. A nested case-control study was conducted with data from the U.S. Department of Defense Serum Repository (DoDSR) cohort between 2000 and 2013 to assess associations of individual OCPs serum concentrations with PTC risk.
METHODS: This study included 742 histologically confirmed PTC cases (341 females, 401 males) and 742 individually-matched controls with pre-diagnostic serum samples selected from the DoDSR. Associations between categories of lipid-corrected serum concentrations of seven OCPs and PTC risk were evaluated for classical PTC and follicular PTC using conditional logistic regression, adjusted for body mass index category and military branch to compute odds ratios (OR) and 95% confidence intervals (CIs). Effect modification by sex, birth cohort, and race was examined.
RESULTS: There was no evidence of associations between most of the OCPs and PTC, overall or stratified by histological subtype. Overall, there was no evidence of an association between hexachlorobenzene (HCB) and PTC, but stratified by histological subtype HCB was associated with significantly increased risk of classical PTC (third tertile above the limit of detection (LOD) vs.
METHODS: This study included 742 histologically confirmed PTC cases (341 females, 401 males) and 742 individually-matched controls with pre-diagnostic serum samples selected from the DoDSR. Associations between categories of lipid-corrected serum concentrations of seven OCPs and PTC risk were evaluated for classical PTC and follicular PTC using conditional logistic regression, adjusted for body mass index category and military branch to compute odds ratios (OR) and 95% confidence intervals (CIs). Effect modification by sex, birth cohort, and race was examined.
RESULTS: There was no evidence of associations between most of the OCPs and PTC, overall or stratified by histological subtype. Overall, there was no evidence of an association between hexachlorobenzene (HCB) and PTC, but stratified by histological subtype HCB was associated with significantly increased risk of classical PTC (third tertile above the limit of detection (LOD) vs.
摘要：
背景：有机氯农药（OCP）暴露对人乳头状甲状腺癌（PTC）发展的影响尚不清楚。在2000年至2013年之间，使用来自美国国防部血清储存库（DoDSR）队列的数据进行了嵌套病例对照研究，以评估个体OCPs血清浓度与PTC风险的关联。
方法：本研究包括742例经组织学证实的PTC患者（341例女性，401名男性）和742名与选自DoDSR的诊断前血清样品单独匹配的对照。使用条件逻辑回归评估了经典PTC和卵泡PTC的7种OCP的脂质校正血清浓度类别与PTC风险之间的关联。根据体重指数类别和军事部门进行调整，以计算优势比(OR)和95%置信区间(CI)。按性别划分的效果修改，出生队列，种族被检查了。
结果：没有证据表明大多数OCP与PTC之间存在关联，整体或按组织学亚型分层。总的来说,没有证据表明六氯苯（HCB）与PTC之间存在关联，但是按组织学亚型HCB分层与经典PTC的风险显着增加有关（检测限（LOD）与
方法：本研究包括742例经组织学证实的PTC患者（341例女性，401名男性）和742名与选自DoDSR的诊断前血清样品单独匹配的对照。使用条件逻辑回归评估了经典PTC和卵泡PTC的7种OCP的脂质校正血清浓度类别与PTC风险之间的关联。根据体重指数类别和军事部门进行调整，以计算优势比(OR)和95%置信区间(CI)。按性别划分的效果修改，出生队列，种族被检查了。
结果：没有证据表明大多数OCP与PTC之间存在关联，整体或按组织学亚型分层。总的来说,没有证据表明六氯苯（HCB）与PTC之间存在关联，但是按组织学亚型HCB分层与经典PTC的风险显着增加有关（检测限（LOD）与
