PDF(Pubmed)
Abstract：
BACKGROUND: Paclitaxel is a chemotherapeutic agent commonly used for ovarian, lung, breast carcinoma, and Kaposi\'s sarcoma. Its common side effects include hypersensitivity reaction, bone marrow suppression, and peripheral neuropathy. However, a rare and life-threatening side effect is paclitaxel-induced myocardial infarction.
METHODS: A 71-year-old man with type 2 diabetes mellitus, hypertension, heavy smoking history, previous coronary artery disease with percutaneous coronary intervention (PCI) in left anterior descending artery (LAD), and non-small lung cancer presented with non-ST elevation myocardial infarction during infusion of paclitaxel infusion. Coronary angiogram showed de novo three vessel disease with 70% stenosis in ostial to distal left main artery (LM) and 80% in-stent re-stenosis in proximal to mid left anterior descending artery.
CONCLUSIONS: Physicians should be keeping this in mind when dealing with patients on paclitaxel, especially if they have previous risk factors for coronary artery disease.
METHODS: A 71-year-old man with type 2 diabetes mellitus, hypertension, heavy smoking history, previous coronary artery disease with percutaneous coronary intervention (PCI) in left anterior descending artery (LAD), and non-small lung cancer presented with non-ST elevation myocardial infarction during infusion of paclitaxel infusion. Coronary angiogram showed de novo three vessel disease with 70% stenosis in ostial to distal left main artery (LM) and 80% in-stent re-stenosis in proximal to mid left anterior descending artery.
CONCLUSIONS: Physicians should be keeping this in mind when dealing with patients on paclitaxel, especially if they have previous risk factors for coronary artery disease.
摘要：
背景：紫杉醇是一种常用于卵巢的化疗药物，肺，乳腺癌,和卡波西肉瘤.其常见的副作用包括过敏反应，骨髓抑制,和周围神经病变。然而,一种罕见且危及生命的副作用是紫杉醇诱导的心肌梗死.
方法：一名71岁的2型糖尿病患者，高血压,大量吸烟史,在左前降支（LAD）行经皮冠状动脉介入治疗（PCI）的既往冠状动脉疾病，和非小细胞肺癌在输注紫杉醇期间出现非ST段抬高型心肌梗死。冠状动脉造影显示新发三支血管疾病，左主动脉（LM）开口至远端狭窄70％，左前降支近端至中段支架内再狭窄80％。
结论：医生在治疗紫杉醇患者时应该牢记这一点，特别是如果他们以前有冠心病的危险因素。
方法：一名71岁的2型糖尿病患者，高血压,大量吸烟史,在左前降支（LAD）行经皮冠状动脉介入治疗（PCI）的既往冠状动脉疾病，和非小细胞肺癌在输注紫杉醇期间出现非ST段抬高型心肌梗死。冠状动脉造影显示新发三支血管疾病，左主动脉（LM）开口至远端狭窄70％，左前降支近端至中段支架内再狭窄80％。
结论：医生在治疗紫杉醇患者时应该牢记这一点，特别是如果他们以前有冠心病的危险因素。
