PDF(Pubmed)
Abstract：
This study aimed to evaluate the effect of previous surgical termination of pregnancy (STP) on pregnancy outcomes in women undergoing FET cycles of IVF/ICSI. Retrospective cohort study. Reproductive Center of Maternal and Child Health Care Hospital in Lianyungang city. Data were selected from all IVF/ICSI FET cycles performed between January 2014 and December 2020. A total of 761 cycles met the criteria were included in this study. The primary outcome measures were clinical pregnancy and live birth rates. Secondary outcome measures were biochemical pregnancy rate, spontaneous abortion rate, and preterm birth rate. After adjustments for a series of potential confounding factors, the previous STP was an influential factor in reducing FET cycle clinical pregnancy rate compared with women who had not previously undergone STP (OR = 0.614, 95% CI 0.413-0.911, P = 0.016). The effect of the previous STP on the live birth rate was not statistically significant. (OR = 0.745, 95% CI 0.495-1.122, P = 0.159). Also, an increase in the number of previous STPs relative to only 1-time abortion was an independent risk factor in reducing clinical pregnancy rate and live birth rate (OR = 0.399,95% CI 0.162-0.982, p = 0.046; OR = 0.32,95% CI 0.119-0.857, p = 0.023). Previous STP was an independent factor contributing to the decline in FET cycle clinical pregnancy rates.
摘要：
这项研究旨在评估先前手术终止妊娠（STP）对接受IVF/ICSIFET周期的女性妊娠结局的影响。回顾性队列研究。连云港市妇幼保健院生殖中心.数据来自2014年1月至2020年12月进行的所有IVF/ICSIFET周期。本研究包括总共761个符合标准的周期。主要结局指标是临床妊娠和活产率。次要结局指标是生化妊娠率，自然流产率,和早产率。在对一系列潜在的混杂因素进行调整后，与未接受过STP的女性相比,既往STP是降低FET周期临床妊娠率的影响因素(OR=0.614,95%CI0.413~0.911,P=0.016).既往STP对活产率的影响无统计学意义。(OR=0.745,95%CI0.495～1.122,P=0.159)。此外，与仅1次流产相比,既往STP数量的增加是降低临床妊娠率和活产率的独立危险因素(OR=0.399,95%CI0.162-0.982,p=0.046;OR=0.32,95%CI0.119-0.857,p=0.023).先前的STP是导致FET周期临床妊娠率下降的独立因素。
