关键词: Antipsychotics Bidirectional link Epileptic seizure Schizophrenia

Mesh : Humans Epilepsy / epidemiology etiology Schizophrenia / epidemiology complications Comorbidity Antipsychotic Agents / adverse effects therapeutic use

来  源:   DOI:10.1016/j.neurol.2024.03.002

Abstract:
Epileptic seizures have been widely considered as a complication of external or iatrogenic factors in schizophrenia. However, epidemiologic, neurodevelopmental and genetic data have changed regards on this topic considering the complexity of the bidirectional link between epilepsy and schizophrenia. We will examine these data constituting the pathophysiological aspects of this particular association and detail the particular impact of antipsychotics on the occurence of epileptic seizure in schizophrenia as well as the management strategies.
摘要:
癫痫发作已被广泛认为是精神分裂症的外部或医源性因素的并发症。然而,流行病学,考虑到癫痫和精神分裂症之间双向联系的复杂性,神经发育和遗传数据改变了对这一主题的看法.我们将研究构成这种特定关联的病理生理方面的这些数据,并详细说明抗精神病药物对精神分裂症中癫痫发作的发生的特殊影响以及管理策略。
公众号