PDF(Pubmed)
Abstract：
BACKGROUND: Perforated peptic ulcers are a life-threatening complication associated with high morbidity and mortality. Several treatment approaches are available. The aim of this network meta-analysis (NMA) is to compare surgical and alternative approaches for the treatment of perforated peptic ulcers regarding mortality and other patient-relevant outcomes.
METHODS: A systematic literature search of PubMed/MEDLINE, Cochrane Library, Embase, CINAHL, ClinicalTrials.gov trial registry and ICTRP will be conducted with predefined search terms.To address the question of the most effective treatment approach, an NMA will be performed for each of the outcomes mentioned above. A closed network of interventions is expected. The standardised mean difference with its 95% CI will be used as the effect measure for the continuous outcomes, and the ORs with 95% CI will be calculated for the binary outcomes.
BACKGROUND: In accordance with the nature of the data used in this meta-analysis, which involves aggregate information from previously published studies ethical approval is deemed unnecessary. Results will be disseminated directly to decision-makers (eg, surgeons, gastroenterologists) through publication in peer-reviewed journals and presentation at conferences.
UNASSIGNED: CRD42023482932.
METHODS: A systematic literature search of PubMed/MEDLINE, Cochrane Library, Embase, CINAHL, ClinicalTrials.gov trial registry and ICTRP will be conducted with predefined search terms.To address the question of the most effective treatment approach, an NMA will be performed for each of the outcomes mentioned above. A closed network of interventions is expected. The standardised mean difference with its 95% CI will be used as the effect measure for the continuous outcomes, and the ORs with 95% CI will be calculated for the binary outcomes.
BACKGROUND: In accordance with the nature of the data used in this meta-analysis, which involves aggregate information from previously published studies ethical approval is deemed unnecessary. Results will be disseminated directly to decision-makers (eg, surgeons, gastroenterologists) through publication in peer-reviewed journals and presentation at conferences.
UNASSIGNED: CRD42023482932.
摘要：
背景：穿孔性消化性溃疡是一种与高发病率和死亡率相关的危及生命的并发症。有几种治疗方法可用。此网络荟萃分析（NMA）的目的是比较手术和替代方法治疗穿孔性消化性溃疡的死亡率和其他患者相关结局。
方法：系统文献检索PubMed/MEDLINE，科克伦图书馆,Embase,CINAHL,ClinicalTrials.gov试验注册和ICTRP将使用预定义的搜索词进行。为了解决最有效的治疗方法的问题，将对上述每个结果进行NMA。预计将有一个封闭的干预网络。其95%CI的标准化平均差将用作连续结果的效果度量，并且将为二元结果计算具有95%CI的OR。
背景：根据本荟萃分析中使用的数据的性质，这涉及来自先前发表的研究的汇总信息，道德批准被认为是不必要的。结果将直接传播给决策者(例如，外科医生,胃肠病学家）通过在同行评审的期刊上发表和在会议上的介绍。
■CRD42023482932。
方法：系统文献检索PubMed/MEDLINE，科克伦图书馆,Embase,CINAHL,ClinicalTrials.gov试验注册和ICTRP将使用预定义的搜索词进行。为了解决最有效的治疗方法的问题，将对上述每个结果进行NMA。预计将有一个封闭的干预网络。其95%CI的标准化平均差将用作连续结果的效果度量，并且将为二元结果计算具有95%CI的OR。
背景：根据本荟萃分析中使用的数据的性质，这涉及来自先前发表的研究的汇总信息，道德批准被认为是不必要的。结果将直接传播给决策者(例如，外科医生,胃肠病学家）通过在同行评审的期刊上发表和在会议上的介绍。
■CRD42023482932。
