Abstract：
The role of cellular senescence in age-related diseases has been fully recognized. In various age-related-chronic lung diseases, the function of alveolar epithelial cells (AECs) is impaired and alveolar regeneration disorders, especially in bronchopulmonary dysplasia，pulmonary fibrosis (PF), chronic obstructive pulmonary disease (COPD), cancer, etc. Except for age-related-chronic lung diseases, an increasing number of studies are exploring the role of cellular senescence in developmental chronic lung diseases, which typically originate in childhood and even in the neonatal period. This review provides an overview of cellular senescence and lung diseases from newborns to the elderly, attempting to draw attention to the relationship between cellular senescence and developmental lung diseases.
摘要：
细胞衰老在年龄相关疾病中的作用已被充分认识。在各种与年龄相关的慢性肺部疾病中，肺泡上皮细胞（AECs）的功能受损和肺泡再生障碍，特别是在支气管肺发育不良，肺纤维化（PF），慢性阻塞性肺疾病(COPD),癌症,等。除了与年龄有关的慢性肺病，越来越多的研究正在探索细胞衰老在慢性肺部疾病中的作用，通常起源于童年，甚至在新生儿期。这篇综述概述了从新生儿到老年人的细胞衰老和肺部疾病，试图提请注意细胞衰老与发育性肺部疾病之间的关系。
