Abstract：
Circular RNAs (circRNAs) have been recognized as key components in the intricate regulatory network of the KRAS pathway across various cancers. The KRAS pathway, a central signalling cascade crucial in tumorigenesis, has gained substantial emphasis as a possible therapeutic target. CircRNAs, a subgroup of non-coding RNAs known for their closed circular arrangement, play diverse roles in gene regulation, contributing to the intricate landscape of cancer biology. This review consolidates existing knowledge on circRNAs within the framework of the KRAS pathway, emphasizing their multifaceted functions in cancer progression. Notable circRNAs, such as Circ_GLG1 and circITGA7, have been identified as pivotal regulators in colorectal cancer (CRC), influencing KRAS expression and the Ras signaling pathway. Aside from their significance in gene regulation, circRNAs contribute to immune evasion, apoptosis, and drug tolerance within KRAS-driven cancers, adding complexity to the intricate interplay. While our comprehension of circRNAs in the KRAS pathway is evolving, challenges such as the diverse landscape of KRAS mutant tumors and the necessity for synergistic combination therapies persist. Integrating cutting-edge technologies, including deep learning-based prediction methods, holds the potential for unveiling disease-associated circRNAs and identifying novel therapeutic targets. Sustained research efforts are crucial to comprehensively unravel the molecular mechanisms governing the intricate interplay between circRNAs and the KRAS pathway, offering insights that could potentially revolutionize cancer diagnostics and treatment strategies.
摘要：
环状RNA（circularRNAs，circRNAs）已被认为是各种癌症中KRAS通路复杂调控网络的关键成分。KRAS途径,在肿瘤发生中至关重要的中央信号级联，作为一个可能的治疗目标已经得到了很大的重视。CircRNAs,一组非编码RNA，以其封闭的圆形排列而闻名，在基因调控中发挥不同的作用，有助于癌症生物学的复杂景观。这篇综述巩固了在KRAS途径框架内对circRNAs的现有知识，强调它们在癌症进展中的多方面功能。值得注意的circRNAs，如Circ_GLG1和cirtitGA7，已被确定为大肠癌（CRC）的关键调节因子，影响KRAS表达和Ras信号通路。除了它们在基因调控中的意义，circRNAs有助于免疫逃避，凋亡，和KRAS驱动的癌症中的药物耐受性，给复杂的相互作用增加了复杂性。虽然我们对KRAS途径中的circRNAs的理解正在发展，KRAS突变肿瘤的多样性和协同联合治疗的必要性等挑战仍然存在。整合尖端技术，包括基于深度学习的预测方法，具有揭示疾病相关的circRNAs和识别新的治疗靶标的潜力。持续的研究努力对于全面解开circRNAs和KRAS通路之间复杂相互作用的分子机制至关重要。提供可能彻底改变癌症诊断和治疗策略的见解。
