PDF(Pubmed)
Abstract：
BACKGROUND: The role of tumor-associated macrophages (TAMs) in patients with esophageal squamous cell carcinoma (ESCC) following surgery remains controversial. Hence, we performed the present study to systematically analyze the prognostic and clinical significance of distinct TAMs biomarkers and distributions in ESCC patients underwent surgery.
METHODS: PubMed, Web of Science, and EMBASE databases were searched up to March 31, 2023. The pooled analysis was conducted to evaluate the effects of TAMs on overall survival (OS), disease-free survival (DFS), and clinicopathological characteristics using fixed-effects or random-effect model.
RESULTS: Involving a total of 2,502 ESCC patients underwent surgery from 15 studies, the results suggested that the total count of CD68+ TAMs was inversely associated with OS and DFS in ESCC patients, which was also noticed in the relationship of CD68+ TAMs in tumor islet (TI) with OS (all P<0.05), although no association between CD68+ TAMs in tumor stroma (TS) and OS (P>0.05). Moreover, either islet or stromal CD163+ TAMs density was a prognostic factor ESCC (all P<0.05). Similarly, an elevated CD204+ TAMs density in TI predicted a poor DFS (P<0.05), although CD204+ TAMs in TI had no relationship with OS (P>0.05). Besides, a high CD68+ TAMs density was significantly associated with lymphatic vessel invasion, vascular invasion, and lymph node metastasis (all P<0.05).
CONCLUSIONS: Our results demonstrated the prognostic and clinical significance of TAMs in ESCC patients underwent surgery. TAMs should be considered a target that could improve prognostic stratification and clinical outcomes in ESCC after surgery.
METHODS: PubMed, Web of Science, and EMBASE databases were searched up to March 31, 2023. The pooled analysis was conducted to evaluate the effects of TAMs on overall survival (OS), disease-free survival (DFS), and clinicopathological characteristics using fixed-effects or random-effect model.
RESULTS: Involving a total of 2,502 ESCC patients underwent surgery from 15 studies, the results suggested that the total count of CD68+ TAMs was inversely associated with OS and DFS in ESCC patients, which was also noticed in the relationship of CD68+ TAMs in tumor islet (TI) with OS (all P<0.05), although no association between CD68+ TAMs in tumor stroma (TS) and OS (P>0.05). Moreover, either islet or stromal CD163+ TAMs density was a prognostic factor ESCC (all P<0.05). Similarly, an elevated CD204+ TAMs density in TI predicted a poor DFS (P<0.05), although CD204+ TAMs in TI had no relationship with OS (P>0.05). Besides, a high CD68+ TAMs density was significantly associated with lymphatic vessel invasion, vascular invasion, and lymph node metastasis (all P<0.05).
CONCLUSIONS: Our results demonstrated the prognostic and clinical significance of TAMs in ESCC patients underwent surgery. TAMs should be considered a target that could improve prognostic stratification and clinical outcomes in ESCC after surgery.
摘要：
背景：肿瘤相关巨噬细胞（TAMs）在食管鳞状细胞癌（ESCC）术后患者中的作用仍存在争议。因此，本研究旨在系统分析ESCC手术患者中不同TAMs生物标志物和分布的预后和临床意义. 方法:PubMed,WebofScience,和EMBASE数据库的搜索时间截至2023年3月31日。进行汇总分析以评估TAM对总生存期（OS）的影响，使用固定效应或随机效应模型的无病生存期（DFS）和临床病理特征。＆＃160;结果：涉及15项研究中的2,502例ESCC患者接受了手术，结果表明，在ESCC患者中，CD68+TAM的总计数与OS和DFS呈负相关，肿瘤胰岛(TI)中CD68+TAMs与OS的关系(均P<0.05),尽管肿瘤间质(TS)中CD68+TAMs与OS无相关性(P＞0.05).此外，胰岛或基质CD163+TAMs密度是ESCC的预后因素（均P<0.05）。同样，TI中CD204+TAM密度升高预测DFS差(P<0.05)，尽管TI中的CD204+TAMs与OS无关（P＞0.05）。此外,高CD68+TAMs密度与淋巴管浸润显著相关，血管浸润,淋巴结转移(P均<0.05)。＆＃160;结论：我们的结果表明TAMs在接受手术的ESCC患者中的预后和临床意义。TAMs应被视为可以改善ESCC术后预后分层和临床结局的目标。。
