PDF(Pubmed)
Abstract：
Objective: To evaluate the efficacy of the fruits of the medicinal plant Forsythia suspensa (Thunb.) Vahl (FS), in treating inflammation-associated diseases through a meta-analysis of animal models, and also probe deeply into the signaling pathways underlying the progression of inflammation. Materials and methods: All data analyses were performed using Review Manager 5.3 and the results are presented as flow diagrams, risk-of-bias summaries, forest plots, and funnel plots. Summary estimates were calculated using a random- or fixed-effect model, depending on the value of I2. Results: Of the 710 records identified in the initial search, 11 were selected for the final meta-analysis. Each study extracted data from the model and treatment groups for analysis, and the results showed that FS alleviated the inflammatory cytokine levels in serum; oxidant indicator: reactive oxygen species; enzymes of liver function; endotoxin and regulatory cells in blood; and improved the antioxidant enzyme superoxide dismutase. Conclusion: FS effectively reversed the change in acute or chronic inflammation indicators in animal models, and the regulation of multiple channel proteins in inflammatory signaling pathways suggests that FS is a good potential drug for inflammatory disease drug therapy.
摘要：
目的:评价药用植物连翘(Thunb.)瓦尔(FS)，通过动物模型的荟萃分析治疗炎症相关疾病，并深入探究炎症进展的信号通路。材料和方法：所有数据分析均使用ReviewManager5.3进行，结果以流程图形式呈现。偏见风险摘要，森林地块,和漏斗图。使用随机或固定效应模型计算汇总估计值，取决于I2的值。结果：在初始搜索中确定的710条记录中，选择11人进行最终的荟萃分析。每个研究都从模型和治疗组中提取数据进行分析，结果表明，FS减轻了血清中的炎症细胞因子水平；氧化剂指标：活性氧；肝功能酶；血液中的内毒素和调节细胞；并提高了抗氧化酶超氧化物歧化酶。结论:FS可有效逆转动物模型急性或慢性炎症指标的变化,和炎症信号通路中的多通道蛋白的调节提示FS是一种很好的潜在的炎症性疾病药物治疗药物。
