Abstract：
UNASSIGNED: Endothelial dysfunction is a major feature of preeclampsia. sVE-cadherin plays a role in the preservation and regulation of the endothelial barrier. For that reason, to evaluation of sVE-cadherin may help elucidate the disease pathophysiology of preeclampsia.
UNASSIGNED: The sample size was calculated as a minimum of 46 pregnant women for each group based on serum sVE-Cadherin levels in a pilot study of 10 preeclamptic and 10 control groups. Hundred-twenty pregnancies complicated with early-onset (n = 60) and late-onset (n = 60) preeclampsia were compared with 120 gestational-age (GA)-matched (±1 week) uncomplicated pregnancies. The venous blood sampling was performed upon preeclampsia diagnosis prior to the onset of the labor in the preeclampsia group and the matching (±1 week) pregnancy week in the control group. Demographic and biochemical parameters were evaluated.
UNASSIGNED: Mean serum sVE-Cadherin was significantly higher in women with EOPE compared to that of the GA-matched control group (5.86 ± 1.57 ng/mL vs. 2.28 ± 0.80 ng/mL, p < 0.001), in women with LOPE compared to that of the GA-matched control group (3.11 ± 0.97 ng/mL vs. 1.69 ± 0.87 ng/mL, p < 0.001), and in women with EOPE compared to that of LOPE group (5.86 ± 1.57 ng/mL vs. 3.11 ± 0.97 ng/mL, p < 0.001) after correction for GA. Serum sVE-Cadherin positively correlated with systolic and diastolic blood pressure and a negative correlation with gestational age at sampling.
UNASSIGNED: The serum level of sVE-Cadherin was higher in women with preeclampsia than that of GA-matched healthy pregnant women, in women with EOPE compared to that of LOPE. sVE-Cadherin is an important marker in early-onset pre-eclampsia with severe clinical findings.
UNASSIGNED: The sample size was calculated as a minimum of 46 pregnant women for each group based on serum sVE-Cadherin levels in a pilot study of 10 preeclamptic and 10 control groups. Hundred-twenty pregnancies complicated with early-onset (n = 60) and late-onset (n = 60) preeclampsia were compared with 120 gestational-age (GA)-matched (±1 week) uncomplicated pregnancies. The venous blood sampling was performed upon preeclampsia diagnosis prior to the onset of the labor in the preeclampsia group and the matching (±1 week) pregnancy week in the control group. Demographic and biochemical parameters were evaluated.
UNASSIGNED: Mean serum sVE-Cadherin was significantly higher in women with EOPE compared to that of the GA-matched control group (5.86 ± 1.57 ng/mL vs. 2.28 ± 0.80 ng/mL, p < 0.001), in women with LOPE compared to that of the GA-matched control group (3.11 ± 0.97 ng/mL vs. 1.69 ± 0.87 ng/mL, p < 0.001), and in women with EOPE compared to that of LOPE group (5.86 ± 1.57 ng/mL vs. 3.11 ± 0.97 ng/mL, p < 0.001) after correction for GA. Serum sVE-Cadherin positively correlated with systolic and diastolic blood pressure and a negative correlation with gestational age at sampling.
UNASSIGNED: The serum level of sVE-Cadherin was higher in women with preeclampsia than that of GA-matched healthy pregnant women, in women with EOPE compared to that of LOPE. sVE-Cadherin is an important marker in early-onset pre-eclampsia with severe clinical findings.
摘要：
■内皮功能障碍是先兆子痫的主要特征。sVE-cadherin在内皮屏障的保护和调节中起作用。出于这个原因,评估sVE-cadherin可能有助于阐明先兆子痫的疾病病理生理学。
■在10个先兆子痫组和10个对照组的初步研究中，根据血清sVE-Cadherin水平，计算出每组最少46名孕妇的样本量。将120例合并早发型（n=60）和晚发型（n=60）先兆子痫的妊娠与120例胎龄（GA）匹配（±1周）的无并发症妊娠进行了比较。在先兆子痫组的分娩开始之前和对照组的匹配（±1周）妊娠周，在先兆子痫诊断时进行静脉血采样。评估人口统计学和生化参数。
■与GA匹配的对照组相比，EOPE女性的平均血清sVE-Cadherin显着更高（5.86±1.57ng/mLvs.2.28±0.80ng/mL，p<0.001)，与GA匹配的对照组相比，LOPE女性（3.11±0.97ng/mLvs.1.69±0.87ng/mL，p<0.001)，在患有EOPE的女性中，与LOPE组相比（5.86±1.57ng/mLvs.3.11±0.97ng/mL，校正GA后p<0.001)。采样时血清sVE-Cadherin与收缩压和舒张压呈正相关，与胎龄呈负相关。
■先兆子痫妇女的血清sVE-Cadherin水平高于GA匹配的健康孕妇，与爱的女性相比。sVE-Cadherin是早发型子痫前期的重要标志物，具有严重的临床表现。
■在10个先兆子痫组和10个对照组的初步研究中，根据血清sVE-Cadherin水平，计算出每组最少46名孕妇的样本量。将120例合并早发型（n=60）和晚发型（n=60）先兆子痫的妊娠与120例胎龄（GA）匹配（±1周）的无并发症妊娠进行了比较。在先兆子痫组的分娩开始之前和对照组的匹配（±1周）妊娠周，在先兆子痫诊断时进行静脉血采样。评估人口统计学和生化参数。
■与GA匹配的对照组相比，EOPE女性的平均血清sVE-Cadherin显着更高（5.86±1.57ng/mLvs.2.28±0.80ng/mL，p<0.001)，与GA匹配的对照组相比，LOPE女性（3.11±0.97ng/mLvs.1.69±0.87ng/mL，p<0.001)，在患有EOPE的女性中，与LOPE组相比（5.86±1.57ng/mLvs.3.11±0.97ng/mL，校正GA后p<0.001)。采样时血清sVE-Cadherin与收缩压和舒张压呈正相关，与胎龄呈负相关。
■先兆子痫妇女的血清sVE-Cadherin水平高于GA匹配的健康孕妇，与爱的女性相比。sVE-Cadherin是早发型子痫前期的重要标志物，具有严重的临床表现。
