Abstract：
The goal of the current study was to assess levels of salivary interleukin (IL)-38, IL-1β, and IL-10 in various periodontal clinical conditions. In total, 60 (20 healthy, 20 gingivitis, and 20 stage II-III, grade A-B periodontitis) subjects were included in the study. Demographic and clinical periodontal parameters were recorded. Samples were examined for IL-38, IL-1β, and IL-10 levels by means of enzyme-linked immunosorbent assay. Results demonstrated that the periodontitis group had significantly lower salivary IL-38 levels (P < 0.05) than the healthy group. Salivary IL-10 levels did not differ significantly between the groups (P > 0.05). The salivary IL-1β levels of gingivitis (P < 0.001) and periodontitis groups (P < 0.01) were significantly higher than those of the healthy group. The present study indicated that IL-38 level is decreased in periodontal disease. The results suggested a possible role of IL-38 in the periodontal inflammation process. Clarifying the mechanisms of IL-38 in the inflammatory process may contribute to the development of novel treatment strategies in periodontal diseases.
摘要：
本研究的目的是评估唾液白细胞介素（IL）-38，IL-1β，和IL-10在各种牙周临床疾病中的作用。总的来说,60（20健康，20牙龈炎，和20阶段II-III，A-B级牙周炎）受试者被纳入研究。记录人口统计学和临床牙周参数。检查样品的IL-38，IL-1β，通过酶联免疫吸附测定和IL-10水平。结果表明，牙周炎组唾液IL-38水平明显低于健康组（P<0.05）。唾液IL-10水平在各组间无显著差异(P>0.05)。牙龈炎组(P<0.001)和牙周炎组(P<0.01)唾液IL-1β水平明显高于健康组。本研究表明，牙周病中IL-38水平降低。结果提示IL-38可能在牙周炎症过程中起作用。阐明IL-38在炎症过程中的作用机制可能有助于牙周疾病新型治疗策略的发展。
