Abstract：
UNASSIGNED: The cross-sectional area (CSA) of the median nerve in Parkinson\'s disease remains unclear.
UNASSIGNED: This meta-analysis assesses median nerve CSA changes in Parkinson\'s using ultrasonography.
UNASSIGNED: PubMed, Web of Science, Scopus, and EBSCO were selectively searched for literature on Parkinson\'s disease, Median nerve, and ultrasonography. Following full-text screening, three studies were included in this meta-analysis with 144 Parkinson\'s disease patients and 127 controls. The primary outcome was the cross-sectional area of the median nerve; other motor parameters were also evaluated.
UNASSIGNED: The cross-sectional area of the median nerve was significantly increased in Parkinson\'s patients compared to controls (p = 0.007); the standardized mean difference was 0.79 [95% CI (0.21 - 1.37)]. The standardized mean difference of the motor parameters of the median nerve, amplitude, and latency was -0.04 [95% CI (-0.85 to 0.77)] and 0.30 [95% CI (-0.04 to 0.64)], respectively, with statistically insignificant (All p > 0.05).
UNASSIGNED: This meta-analysis concluded that the cross-sectional area of the median nerve is increased in Parkinson\'s disease patients. The increase in the CSA of the median nerve might explain the higher prevalence of carpal tunnel syndrome in Parkinson\'s disease. Further studies are needed to quantify carpal tunnel syndrome prevalence accurately in Parkinson\'s.
UNASSIGNED: Heterogeneity exists due to non-standardized CSA calculation methods and varied disease stages. Finger movement during ultrasound may introduce artifacts, compromising CSA measurement accuracy. Establishing a definitive CSA cut-off for carpal tunnel syndrome in Parkinson\'s requires further investigation.
UNASSIGNED: This meta-analysis assesses median nerve CSA changes in Parkinson\'s using ultrasonography.
UNASSIGNED: PubMed, Web of Science, Scopus, and EBSCO were selectively searched for literature on Parkinson\'s disease, Median nerve, and ultrasonography. Following full-text screening, three studies were included in this meta-analysis with 144 Parkinson\'s disease patients and 127 controls. The primary outcome was the cross-sectional area of the median nerve; other motor parameters were also evaluated.
UNASSIGNED: The cross-sectional area of the median nerve was significantly increased in Parkinson\'s patients compared to controls (p = 0.007); the standardized mean difference was 0.79 [95% CI (0.21 - 1.37)]. The standardized mean difference of the motor parameters of the median nerve, amplitude, and latency was -0.04 [95% CI (-0.85 to 0.77)] and 0.30 [95% CI (-0.04 to 0.64)], respectively, with statistically insignificant (All p > 0.05).
UNASSIGNED: This meta-analysis concluded that the cross-sectional area of the median nerve is increased in Parkinson\'s disease patients. The increase in the CSA of the median nerve might explain the higher prevalence of carpal tunnel syndrome in Parkinson\'s disease. Further studies are needed to quantify carpal tunnel syndrome prevalence accurately in Parkinson\'s.
UNASSIGNED: Heterogeneity exists due to non-standardized CSA calculation methods and varied disease stages. Finger movement during ultrasound may introduce artifacts, compromising CSA measurement accuracy. Establishing a definitive CSA cut-off for carpal tunnel syndrome in Parkinson\'s requires further investigation.
摘要：
背景：帕金森病正中神经的横截面积（CSA）尚不清楚。目的：本荟萃分析使用超声检查评估帕金森患者的正中神经CSA变化。方法:PubMed,WebofScience,Scopus,和EBSCO选择性地搜索有关帕金森病的文献，正中神经,和超声检查。经过全文筛选,这项荟萃分析包括144例帕金森病患者和127例对照者的三项研究。主要结果是正中神经的横截面积；还评估了其他运动参数。结果：与对照组相比，帕金森病患者的正中神经横截面积显著增加(P=0.007)；标准化平均差异为0.79[95%CI(0.21-1.37)]。正中神经运动参数的标准化平均差，振幅,潜伏期为-0.04[95%CI（-0.85至0.77）]和0.30[95%CI（-0.04至0.64）]，分别,差异无统计学意义(均P>0.05)。结论：这项荟萃分析得出的结论是，帕金森病患者的正中神经横截面积增加。正中神经CSA的增加可能解释了帕金森病中腕管综合征患病率较高的原因。需要进一步的研究来准确量化帕金森氏症中腕管综合征的患病率。局限性：由于非标准化的CSA计算方法和不同的疾病阶段，存在异质性。超声期间的手指运动可能会引入伪影，影响CSA测量精度。建立帕金森氏症腕管综合征的明确CSA截止点需要进一步研究。
